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diphtheria - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

diphtheria

MONDO:0005504

Also known as:Corynebacterium infection

Find Clinical TrialsTrials

Overview

A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.

Treatments1 FDA approved

Clinical Trials22 registered · 7 recruiting

Diagnosis

Biomarker and diagnostic research for diphtheria has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for diphtheria, including ERYTHROMYCIN (ERYTHROMYCIN, approved 1981).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

22 clinical trials registered, 7 recruiting. Interventions under study include biologic therapy and other interventions. Pipeline includes 3 PHASE4, 7 PHASE3, 3 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06997627](https://clinicaltrials.gov/study/NCT06997627)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 8:23 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1679

GARD

Genetic and Rare Diseases Info Center

GARD:1875

Questions for Your Care Team

→What are the benefits and potential side effects of ERYTHROMYCIN for managing diphtheria?
→Are any of the 22 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Disease patterns and progression	40	36%
Research summaries	25	22%
Clinical study results	13	12%
Laboratory research	13	12%
Patient case studies	10	9%
Other research	5	4%
New treatment approaches	4	4%
Testing and diagnosis research	2	2%

Kisho

diphtheria

Overview

Diagnosis

Treatment

Approved Therapies

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

A complex case of diphtheria in a pediatric patient: complications of renal failure and myocarditis.

diphtheria

Overview

Diagnosis

Treatment

Approved Therapies

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

A complex case of diphtheria in a pediatric patient: complications of renal failure and myocarditis.