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A contagious bacterial infection caused by spirochetes of the genus Leptospira. Humans are infected by contact with water and soil which have been contaminated with animal waste products. The signs and symptoms include an initial flu-like phase, followed by a second phase in which patients may develop meningitis, liver failure and renal failure.
Biomarker and diagnostic research for leptospirosis has been reported in the published literature.
Estimated prevalence: 1-9 in 1,000,000 (Rare).
12 clinical trials registered, 4 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and procedural interventions. Pipeline includes 1 PHASE4, 1 PHASE2, 5 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04288674](https://clinicaltrials.gov/study/NCT04288674) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Leptospirosis Registry - LeptoScope |
— |
University of Cologne |
RECRUITING |
[NCT07358910](https://clinicaltrials.gov/study/NCT07358910) | Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective | — | Institut Pasteur du Cambodge | RECRUITING |
[NCT05425524](https://clinicaltrials.gov/study/NCT05425524) | Leptospirosis Care Bundle Study | NA | Chulalongkorn University | RECRUITING |
[NCT07127718](https://clinicaltrials.gov/study/NCT07127718) | Preventive Strategies for Early and Late Complications of Leptospirosis | PHASE2 | National Kidney and Transplant Institute, Philippines | RECRUITING |
372 publications have been identified in PubMed for leptospirosis. Kisho has analyzed 234 by research type. Research spans Epidemiology / Natural History (38%), Review / Meta-Analysis (22%), and Case Report / Case Series (14%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 89 | 38% |
Research summaries | 52 | 22% |
Patient case studies | 33 | 14% |
Laboratory research | 31 | 13% |
Testing and diagnosis research | 14 | 6% |
New treatment approaches | 6 | 3% |
Clinical study results | 5 | 2% |
Other research | 4 | 2% |
Gunathilaka N (2026). [PMID: 41526844](https://pubmed.ncbi.nlm.nih.gov/41526844/). *BMC infectious diseases*. [Epidemiology / Natural History]
Sudhakar Rao M (2026). [PMID: 42081047](https://pubmed.ncbi.nlm.nih.gov/42081047/). *Infection*. [Case Report / Case Series]
Gautam H (2026). [PMID: 41524783](https://pubmed.ncbi.nlm.nih.gov/41524783/). *Arch Microbiol*. [Gene Therapy / Novel Therapeutics]
Kannan EP (2026). [PMID: 41669918](https://pubmed.ncbi.nlm.nih.gov/41669918/). *Analyst*. [Review / Meta-Analysis]
Yosef DK (2026). [PMID: 42057013](https://pubmed.ncbi.nlm.nih.gov/42057013/). *BMC Public Health*. [Epidemiology / Natural History]
Crump JA (2026). [PMID: 41099521](https://pubmed.ncbi.nlm.nih.gov/41099521/). *The Journal of infectious diseases*. [Epidemiology / Natural History]
Rabbi F (2026). [PMID: 42254123](https://pubmed.ncbi.nlm.nih.gov/42254123/). *Ann Med Surg (Lond)*. [Case Report / Case Series]
Jaramillo NM (2026). [PMID: 42242408](https://pubmed.ncbi.nlm.nih.gov/42242408/). *Acta Trop*. [Basic Science / Preclinical]
Chen X (2026). [PMID: 41534637](https://pubmed.ncbi.nlm.nih.gov/41534637/). *Acta Trop*. [Epidemiology / Natural History]
Torres-Higuera LD (2026). [PMID: 41578091](https://pubmed.ncbi.nlm.nih.gov/41578091/). *World J Microbiol Biotechnol*. [Basic Science / Preclinical]
AI-curated news mentioning leptospirosis
Updated Aug 7, 2026
A case report highlights the use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in a patient with severe leptospirosis complicated by pulmonary hemorrhage and refractory acute respiratory distress syndrome. This literature review may provide insights into potential treatment strategies for similar severe cases.
A case report from Iran highlights suspected myocarditis as a complication of leptospirosis. This finding may prompt further investigation into the cardiovascular effects of leptospirosis.
The CDC provides a clinical overview of leptospirosis, offering guidance for healthcare providers on patient care and laboratory practices. This resource aims to enhance understanding and management of the disease among clinicians.
The CDC provides an overview of leptospirosis, detailing symptoms, treatment options, and prevention strategies. This resource aims to enhance public awareness and understanding of the disease.