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Back to Drug-Resistant Tuberculosis

Drug-Resistant Tuberculosis — NIH Grants & Funding

Active and recent NIH-funded research on Drug-Resistant Tuberculosis. Data from NIH RePORTER, last 36 months.

MONDO:0041806

NIH-funded research on Drug-Resistant Tuberculosis

active grants

institutions

125

researchers

new in last 12 mo.

$149.8M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(30)

Basic ScienceR01Active

Understanding resistance and tolerance to nitroimidazoles in Mycobacterium tuberculosis

EHRT, SABINE et al.·WEILL MEDICAL COLL OF CORNELL UNIV·NEW YORK, NY

$2,944,529 (FY2025)

Drug-Resistant Tuberculosis — NIH Grants & Funding

Basic Science(30)

Understanding resistance and tolerance to nitroimidazoles in Mycobacterium tuberculosis

Harnessing potent next-generation diarylquinolines for long-acting injectable formulations to prevent and treat tuberculosis

A systems analysis of drug tolerance in Mycobacterium tuberculosis

Unraveling the spectrum of intrabacterial amide hydrolysis to develop new classes of pyrazinoic acid prodrugs against pyrazinamide resistant Mycobacterium tuberculosis

Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET Imaging

Elucidating the Role of Extracellular Polyphosphate in Mycobacterium tuberculosis Antibiotic Tolerance.

Mechanism of macrophage efflux system in Mycobacterium tuberculosis pathogenesis

Emergence of bedaquiline and clofazimine resistance after interruption of drug-resistant TB therapy in a high HIV prevalence setting

Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistance

Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosis

Translational(32)

Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) Consortium

Optimizing Multi-drug Mycobacterium tuberculosis Therapy for Rapid Sterilization and Resistance Suppression

Teixobactin Development for Tuberculosis

Optimization of Antitubercular Compounds Against a Novel Mycobacterium tuberculosis target, AspC

Advanced Genotypic and Phenotypic monitoring of Drug Resistant TB to Improve TB Treatment Outcomes

Development of a Rapid Phenotypic Pyrazinamide Susceptibility Testing for Mycobacterium tuberculosis Using Well-Standardized Protocol

A Preclinical Program for Targeting Mycobacterium tuberculosis KasA

Development of 1,2,4-Triazolyl Compounds and their derivatives as a New Treatment for Tuberculosis

Development of a highly-multiplexed CRISPR-based TB drug susceptibility test

Development of Novel mRNA Vaccines Against Mycobacterium tuberculosis

Clinical(21)

Strengthening evidence on optimal multidrug-resistant tuberculosis treatment regimens through improved epidemiologic methods

A clinical decision tool to optimize the selection of antibiotics for patients with rifampicin-resistant Tuberculosis

A novel cartridge-based sequencing solution for decentralized M. tuberculosis resistance detection

Poor Treatment Response and Outcomes in Bedaquiline-Based Treatment Regimens for Drug-Resistant Tuberculosis in South Africa

Baseline pRescription According to Direct from Sputum Sequencing and TArgeted drug Concentration Strategy (BRASS TACS)

Non-tuberculous mycobacterium and B cells in the stimulation of ectopic germinal centers and immunological control of pulmonary tuberculosis

Therapeutic drug monitoring for linezolid in the treatment of rifampin-resistant tuberculosis: a pragmatic randomized controlled trial

Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa

Mentoring Multidisciplinary Research in MDR-TB Adherence and the Emergent Drug Resistance

Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

Epi / Nat. History(10)

Emergence of bedaquiline, pretomanid and linezolid resistance after implementation of new drug-resistant tuberculosis regimens in South Africa

Sentinel populations and transmission hotspots of isoniazid-resistant tuberculosis

Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection

Longitudinal microbiome-host interactions and clinical outcomes in drug-resistant tuberculosis patients

Using the Mycobacterium tuberculosis Genome to Predict Tuberculosis Pathology, Drug Resistance Acquisition and Identify Community Transmission Sites

Transmission of drug-resistant tuberculosis in a South African city with a high prevalence of HIV infection

Multidrug-resistant tuberculosis and HIV: Composition of Strains and biomarkers of treatment response

Investigating Transmission Risk and Incidence of Extensively Drug-Resistant Tuberculosis in South Africa

Understanding and Predicting Loss to Follow-up from Multi-Drug Resistant Tuberculosis Treatment in the Setting of High-HIV Burden

Understanding HIV's impact on RR/MDR-TB development and transmission through genomics

Biomarker / Dx(11)

Improving rapid phenotypic drug susceptibility testing for drug resistant tuberculosis in high-burden areas

Rapid phenotypic detection of complex and emergent TB drug-resistance using a next-generation nanoluciferase reporter phage

Automated Sequencing for Culture-free Diagnosis of Drug Resistant TB

Mtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHP

Evolution, transmission, and control of drug-resistant tuberculosis

A Rapid Phenotypic Drug Susceptibility Testing System for Tuberculosis

Handheld and population-based sequencing for rapid detection of new and repurposed drug resistance in M. tuberculosis

Targeting non-coding RNAs as host-directed drug therapy for tuberculosis

Development of a Next-generation Rapid Phenotypic Assay for Drug-Resistant M. tuberculosis

Novel next-generation sequencing assay for monitoring multidrug resistant tuberculosis treatment in the setting of HIV infection

Medical Device(3)

3STEP: A swab-seal-read assay for tuberculosis and RIF resistance enabled by autonomous extraction technology

Innovating anti-tuberculosis drug susceptibility testing with a novel and rapid non-culture based phenotypic test using MPT64 biomarker

Rapid Drug Susceptibility Test for Tuberculosis

Other(2)

Dual Targeting of Mtb Resistance Mechanisms

Novel Stem Cell Immunotherapy for MDR-Tuberculosis