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Multiple familial keratoacanthoma (KA) of Witten and Zak is a rare a rare inherited skin cancer syndrome and is characterized by the coexistence of features characteristic of both multiple KA, Ferguson Smith type and generalized eruptive keratoacanthoma, such as multiple small miliary-type lesions, larger self-healing lesions, and nodulo-ulcerative lesions. Lesions do not have a predilection for the mucosal surfaces. Transmission is autosomal dominant.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for familial keratoacanthoma.
4 publications have been identified in PubMed for familial keratoacanthoma. Kisho has analyzed 3 by research type. Research spans Review / Meta-Analysis (67%) and Case Report / Case Series (33%).
Dobre A (2025). [PMID: 39572470](https://pubmed.ncbi.nlm.nih.gov/39572470/). *Am J Clin Dermatol*. [Review / Meta-Analysis]
Yu Z (2025). [PMID: 41127008](https://pubmed.ncbi.nlm.nih.gov/41127008/). *Front Oncol*. [Case Report / Case Series]
Ochoa-Mellado IG (2025). [PMID: 40649916](https://pubmed.ncbi.nlm.nih.gov/40649916/). *Int J Mol Sci*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 7:43 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center