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A focal epilepsy syndrome where the age at onset is typically in adolescence or adulthood. Affected individuals have focal aware seizures with mesial temporal lobe features, especially prominent déjà vu. Most patients have a normal MRI, and seizures respond to treatment. A subgroup is recognised that have antecedent febrile seizures, hippocampal atrophy, and drug resistant seizures. Direct questioning of relatives may be required to identify this familial epilepsy syndrome, as many individuals consider their déjà vu experiences as mild and they may not have been diagnosed as seizures.
No clinical trials have been registered for familial mesial temporal lobe epilepsy.
2 publications have been identified in PubMed for familial mesial temporal lobe epilepsy. Research spans Case Report / Case Series (100%).
Wang C (2025). [PMID: 41177904](https://pubmed.ncbi.nlm.nih.gov/41177904/). *Acta epileptologica*. [Case Report / Case Series]
Wang C (2024). [PMID: 39029408](https://pubmed.ncbi.nlm.nih.gov/39029408/). *Seizure*. [Case Report / Case Series]
Data assembled from 2 of 12 sources · Last updated Sep 19, 2026, 11:56 AM UTC