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febrile infection-related epilepsy syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

febrile infection-related epilepsy syndrome

MONDO:0015584

Also known as:AERRPSDESC syndromeFIRES

Find Clinical TrialsTrials

Overview

A rare, potentially fatal, epileptic encephalopathy characterized by explosive-onset of recurrent multifocal and bilateral tonic-clonic seizures following an unspecific febrile illness. The syndrome develops without a clear acute structural, toxic or metabolic cause, in a patient without previous epilepsy. FIRES is a subgroup of new-onset refractory status epilepticus (NORSE), and requires a preceding febrile infection as a mandatory feature.

Clinical Trials1 registered

Diagnosis

Biomarker and diagnostic research for febrile infection-related epilepsy syndrome has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE3. Research is primarily sponsored by academic and government institutions.

95 publications have been identified in PubMed for febrile infection-related epilepsy syndrome. Research spans Case Report / Case Series (33%), Epidemiology / Natural History (29%), and Review / Meta-Analysis (22%).

Research Type	Count	% of Total
Patient case studies	31

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 4:52 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:163703

GARD

Genetic and Rare Diseases Info Center

GARD:11005

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

febrile infection-related epilepsy syndrome

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Superfast VNS Titration for the Treatment of SRSE in the Acute Phase of FIRES: A Pediatric Case Report and Literature Review.

febrile infection-related epilepsy syndrome

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Superfast VNS Titration for the Treatment of SRSE in the Acute Phase of FIRES: A Pediatric Case Report and Literature Review.