Hailey-Hailey disease

Hailey-Hailey disease, also known as benign chronic familial pemphigus of Hailey-Hailey, is a rare skin condition that mainly affects areas such as the armpits, groin, and other skin folds. The condition is characterized by rhagades, which are splits or fissures in the skin. This condition is familial, meaning it can run in families. Its name, 'benign chronic familial pemphigus,' indicates that while the condition may recur and persist over time, it is generally not life-threatening. The changes in the skin typically occur in the armpits, inguinal, and perineal regions including the scrotum or vulva.

People with this condition often experience painful splits or fissures in the skin, especially in areas such as the armpits and the folds of the groin and perineal region. These skin changes are the main symptoms observed in Hailey-Hailey disease.

Hailey-Hailey disease is linked to changes in the ATP2C1 gene. This gene plays a role in the normal function of skin cells. The familial nature of the condition suggests that it is inherited, although more detailed risk factors are not provided in the available information.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research is currently limited for this condition.