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pemphigoid gestationis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pemphigoid gestationis

MONDO:0006558

Also known as:Herpes gestationisHerpes gestationis (disorder)Herpes gestationis NOS (disorder)

Overview

A rare pregnancy-associated autoimmune skin disease that is characterized by an itchy rash that develops into blisters. It is most common during the second and third trimesters of pregnancy. It was previously known as herpes gestationis although it has no association with the herpes virus whatsoever.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Pruritus, Premature birth, Abnormal blistering of the skin, and Skin vesicle; and common findings: Failure to thrive and Intrauterine growth retardation.

Organ System	Phenotype Count	Example Features
Skin	3	Pruritus, Abnormal blistering of the skin, Skin vesicle

Prognosis

Phenotype severity distribution: 4 very common features, 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for pemphigoid gestationis.

36 publications have been identified in PubMed for pemphigoid gestationis. Research spans Case Report / Case Series (42%), Review / Meta-Analysis (36%), and Other (11%).

Research Type	Count	% of Total
Patient case studies	15	42%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:43 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:63275

GARD

Genetic and Rare Diseases Info Center

GARD:6497

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

pemphigoid gestationis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Itchy, blistering rash in pregnancy: pemphigoid gestationis.

Optimizing Local Treatment in Pemphigus and Pemphigoid: Current Evidence and Unmet Needs.

pemphigoid gestationis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Itchy, blistering rash in pregnancy: pemphigoid gestationis.

Optimizing Local Treatment in Pemphigus and Pemphigoid: Current Evidence and Unmet Needs.