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pemphigus foliaceus (PF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pemphigus foliaceus

MONDO:0019324

Also known as:PF

Find Clinical TrialsTrials

Overview

Pemphigus foliaceous is a rare superficial pemphigus disease characterized by multiple, pruritic, scaly, crusted cutaneous erosions, with flaky circumscribed patches, localized mostly on the face, scalp, trunk and extremities, often presenting an erythematous base. Mucosal involvement is rarely observed.

Clinical Trials1 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Autoimmunity and Acantholysis; and common findings: Pruritus, Abnormal scalp morphology, Crusting erythematous dermatitis, and Abnormal blistering of the skin and others. 20 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	10	Pruritus, Crusting erythematous dermatitis, Abnormal blistering of the skin

Diagnosis

Biomarker and diagnostic research for pemphigus foliaceus has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 very common features, 8 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

134 publications have been identified in PubMed for pemphigus foliaceus. Research spans Case Report / Case Series (36%), Review / Meta-Analysis (13%), and Basic Science / Preclinical (11%).

Research Type	Count	% of Total
Patient case studies	48	36%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 3:00 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:79481

GARD

Genetic and Rare Diseases Info Center

GARD:7354

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

pemphigus foliaceus

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.

Family burden of disease in pemphigus: a cross-sectional survey.

Optimizing Local Treatment in Pemphigus and Pemphigoid: Current Evidence and Unmet Needs.

pemphigus foliaceus

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.

Family burden of disease in pemphigus: a cross-sectional survey.

Optimizing Local Treatment in Pemphigus and Pemphigoid: Current Evidence and Unmet Needs.