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hereditary inclusion body myopathy type 4 (HIBM4) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary inclusion body myopathy type 4

MONDO:0017931

Also known as:HIBM4

Overview

Hereditary inclusion body myopathy type 4 is a rare non-dystrophic myopathy characterized by slowly progressive muscular weakness and atrophy initially involving proximal lower limbs and hip girdle and later on shoulder girdle, proximal upper limbs and axial muscles. Ambulation is usually preserved. Congophilic inclusions with cytoplasmic inclusions of 15-21 nm filaments on electron microscopy are revealed in muscle biopsy.

ResearchLimited published research (7 articles)

Diagnosis

Biomarker and diagnostic research for hereditary inclusion body myopathy type 4 has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary inclusion body myopathy type 4.

7 publications have been identified in PubMed for hereditary inclusion body myopathy type 4. Research spans Review / Meta-Analysis (29%), Basic Science / Preclinical (29%), and Epidemiology / Natural History (29%).

Recent Publications

Boonsri P (2026). [PMID: 41575995](https://pubmed.ncbi.nlm.nih.gov/41575995/). *PloS one*. [Diagnostic / Biomarker]
Koles K (2026). [PMID: 41708000](https://pubmed.ncbi.nlm.nih.gov/41708000/). *The Journal of biological chemistry*. [Review / Meta-Analysis]
Kim DW (2026). [PMID: 41963465](https://pubmed.ncbi.nlm.nih.gov/41963465/). *Exp Mol Med*. [Basic Science / Preclinical]
Pugliese A (2025). [PMID: 40447857](https://pubmed.ncbi.nlm.nih.gov/40447857/). *Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology*. [Epidemiology / Natural History]
Pereira BL (2025). [PMID: 40054019](https://pubmed.ncbi.nlm.nih.gov/40054019/). *Molecular genetics and metabolism*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 6:01 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:324381

GARD

Genetic and Rare Diseases Info Center

GARD:21440

Questions for Your Care Team

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hereditary inclusion body myopathy type 4

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team