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An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes.
Biomarker and diagnostic research for histiocytic sarcoma has been reported in the published literature.
4 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 3 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
150 publications have been identified in PubMed for histiocytic sarcoma. Research spans Case Report / Case Series (56%), Basic Science / Preclinical (16%), and Review / Meta-Analysis (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 84 |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 12:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research | 24 | 16% |
Research summaries | 12 | 8% |
Testing and diagnosis research | 11 | 7% |
Clinical study results | 6 | 4% |
Disease patterns and progression | 6 | 4% |
New treatment approaches | 5 | 3% |
Other research | 2 | 1% |
Tinoco G (2026). [PMID: 41749894](https://pubmed.ncbi.nlm.nih.gov/41749894/). *Cancers*. [Case Report / Case Series]
Sirotnikov S (2026). [PMID: 41617646](https://pubmed.ncbi.nlm.nih.gov/41617646/). *Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society*. [Case Report / Case Series]
Meistro F (2026). [PMID: 41540969](https://pubmed.ncbi.nlm.nih.gov/41540969/). *Vet Clin Pathol*. [Case Report / Case Series]
Largeaud L (2026). [PMID: 41798885](https://pubmed.ncbi.nlm.nih.gov/41798885/). *EJHaem*. [Gene Therapy / Novel Therapeutics]
Wei H (2026). [PMID: 42116046](https://pubmed.ncbi.nlm.nih.gov/42116046/). *BMC Urol*. [Case Report / Case Series]
Ruggeri L (2026). [PMID: 41660350](https://pubmed.ncbi.nlm.nih.gov/41660350/). *Surg Neurol Int*. [Case Report / Case Series]
Lollo G (2026). [PMID: 41994862](https://pubmed.ncbi.nlm.nih.gov/41994862/). *J Feline Med Surg*. [Diagnostic / Biomarker]
Aradilla N (2026). [PMID: 41615264](https://pubmed.ncbi.nlm.nih.gov/41615264/). *Vet Med Sci*. [Case Report / Case Series]
Delio M (2026). [PMID: 42208771](https://pubmed.ncbi.nlm.nih.gov/42208771/). *Hum Pathol*. [Review / Meta-Analysis]
Li J (2026). [PMID: 41058101](https://pubmed.ncbi.nlm.nih.gov/41058101/). *Applied immunohistochemistry & molecular morphology : AIMM*. [Case Report / Case Series]
AI-curated news mentioning histiocytic sarcoma
Updated Aug 21, 2026
Recent research highlights significant clinical improvement in patients with histiocytic sarcoma, suggesting potential new avenues for treatment. The findings may influence future therapeutic strategies for this rare malignancy.
A recent case report details a rare instance of intracranial histiocytic sarcoma, contributing to the limited literature on this aggressive disease. The findings may enhance understanding and treatment approaches for similar cases.
A case report details a 93-year-old patient with histiocytic sarcoma presenting as a submandibular mass. This case contributes to the understanding of the clinical presentation of this rare disease.