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A rare skin disorder of unknown etiology affecting children. It is a photodermatitis, characterized by the formation of vesicles and scarring on sun exposed areas.
Features include always present findings: Cutaneous photosensitivity, Hydroa vacciniforme, and Scarring; and very common findings: Malar rash and Papulovesicular eruption. 17 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 6 | Cutaneous photosensitivity, Malar rash, Papulovesicular eruption |
Biomarker and diagnostic research for hydroa vacciniforme has been reported in the published literature.
Phenotype severity distribution: 3 always present features, 2 very common features.
Estimated prevalence: 1-9 in 1,000,000 (Rare).
2 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.
30 publications have been identified in PubMed for hydroa vacciniforme. Research spans Case Report / Case Series (63%), Diagnostic / Biomarker (11%), and Basic Science / Preclinical (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 17 |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:48 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Eyes
1 |
Keratitis |
Brain and nerves | 1 | Headache |
Testing and diagnosis research | 3 | 11% |
Laboratory research | 3 | 11% |
Other research | 2 | 7% |
Research summaries | 2 | 7% |
Jiang HY (2026). [PMID: 41891350](https://pubmed.ncbi.nlm.nih.gov/41891350/). *J Cutan Med Surg*. [Case Report / Case Series]
Warner-Levy J (2026). [PMID: 42057334](https://pubmed.ncbi.nlm.nih.gov/42057334/). *Photodermatol Photoimmunol Photomed*. [Case Report / Case Series]
Fuseya A (2026). [PMID: 42108635](https://pubmed.ncbi.nlm.nih.gov/42108635/). *Br J Haematol*. [Diagnostic / Biomarker]
Zhang Q (2026). [PMID: 41905747](https://pubmed.ncbi.nlm.nih.gov/41905747/). *Br J Haematol*. [Diagnostic / Biomarker]
Hu R (2026). [PMID: 42021201](https://pubmed.ncbi.nlm.nih.gov/42021201/). *BMC Pediatr*. [Case Report / Case Series]
Luniewski A (2026). [PMID: 41657941](https://pubmed.ncbi.nlm.nih.gov/41657941/). *Lymphatics*. [Basic Science / Preclinical]
Luniewski A (2026). [PMID: 41072584](https://pubmed.ncbi.nlm.nih.gov/41072584/). *J Am Acad Dermatol*. [Basic Science / Preclinical]
Yang C (2026). [PMID: 42057801](https://pubmed.ncbi.nlm.nih.gov/42057801/). *Clin Cosmet Investig Dermatol*. [Case Report / Case Series]
Yabushita T (2026). [PMID: 40707220](https://pubmed.ncbi.nlm.nih.gov/40707220/). *Intern Med*. [Case Report / Case Series]
Hawai SR (2026). [PMID: 42153906](https://pubmed.ncbi.nlm.nih.gov/42153906/). *J Eur Acad Dermatol Venereol*. [Case Report / Case Series]
AI-curated news mentioning hydroa vacciniforme
Updated Apr 24, 2026
A recent publication discusses the clinical features and diagnostic criteria for hydroa vacciniforme, a rare photosensitive condition. The article emphasizes the importance of early recognition and management to improve patient outcomes.