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lipodermatosclerosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

lipodermatosclerosis

MONDO:0023646

Also known as:acute lipodermatosclerosishypodermitis sclerodermaformissclerosing panniculitis

Overview

Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.

Diagnosis

Biomarker and diagnostic research for lipodermatosclerosis has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for lipodermatosclerosis.

22 publications have been identified in PubMed for lipodermatosclerosis. Research spans Review / Meta-Analysis (27%), Case Report / Case Series (27%), and Epidemiology / Natural History (18%).

Research Type	Count	% of Total
Research summaries	6	27%

Data assembled from 2 of 12 sources · Last updated Sep 19, 2026, 11:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:9671

Questions for Your Care Team

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lipodermatosclerosis

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

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Questions for Your Care Team

Questions for Your Care Team

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