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hypertrophic cardiomyopathy 15 (CMH15) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hypertrophic cardiomyopathy 15

MONDO:0013200

Also known as:CMH15VCL hypertrophic cardiomyopathycardiomyopathy familial hypertrophic 15

Overview

Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the VCL gene.

GeneticsAutosomal dominant · VCL (chr 10)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Myofiber disarray, Cardiomyocyte hypertrophy, Hyperdynamic left ventricular ejection fraction, and Apical hypertrophic cardiomyopathy and others.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	7	Hyperdynamic left ventricular ejection fraction, Apical hypertrophic cardiomyopathy, High blood pressure in lung arteries (pulmonary arterial hypertension)

Genetic Landscape

VCL function has not been fully characterized.

Hypertrophic cardiomyopathy 15 is associated with mutations in the VCL gene on chromosome 10.

Diagnosis

Genetic testing for VCL is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hypertrophic cardiomyopathy 15 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 10 always present features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hypertrophic cardiomyopathy 15.

253 publications have been identified in PubMed for hypertrophic cardiomyopathy 15. Research spans Epidemiology / Natural History (22%), Clinical Trial Publication (22%), and Basic Science / Preclinical (19%).

Research Type	Count	% of Total
Disease patterns and progression	56	22%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:45 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:613255

Questions for Your Care Team

→Should I pursue genetic testing for VCL, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hypertrophic cardiomyopathy 15

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

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hypertrophic cardiomyopathy 15

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications