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Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.
Biomarker and diagnostic research for hypogonadotropic hypogonadism has been reported in the published literature.
12 clinical trials registered, 6 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and procedural interventions. Pipeline includes 1 PHASE3, 2 PHASE2, 4 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07224438](https://clinicaltrials.gov/study/NCT07224438) |
Data assembled from 4 of 12 sources · Last updated Oct 4, 2026, 3:02 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea |
PHASE2 |
Stephanie B. Seminara, MD |
RECRUITING |
[NCT05896293](https://clinicaltrials.gov/study/NCT05896293) | Kisspeptin Administration Subcutaneously to Patients With IHH | PHASE2 | Stephanie B. Seminara, MD | RECRUITING |
[NCT06357442](https://clinicaltrials.gov/study/NCT06357442) | Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant. | — | University of Colorado, Denver | RECRUITING |
[NCT01601171](https://clinicaltrials.gov/study/NCT01601171) | Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate | — | Centre Hospitalier Universitaire Vaudois | RECRUITING |
[NCT06583408](https://clinicaltrials.gov/study/NCT06583408) | The REgistry of Very Early Estrogen and AnovuLation | — | Mayo Clinic | RECRUITING |
241 publications have been identified in PubMed for hypogonadotropic hypogonadism. Research spans Review / Meta-Analysis (38%), Case Report / Case Series (24%), and Epidemiology / Natural History (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 76 | 38% |
Patient case studies | 48 | 24% |
Disease patterns and progression | 26 | 13% |
Laboratory research | 20 | 10% |
Clinical study results | 11 | 5% |
Testing and diagnosis research | 8 | 4% |
Other research | 6 | 3% |
New treatment approaches | 6 | 3% |
Fausto JS (2026). [PMID: 40924640](https://pubmed.ncbi.nlm.nih.gov/40924640/). *Neuroendocrinology*. [Basic Science / Preclinical]
Pierret ACS (2026). [PMID: 39834030](https://pubmed.ncbi.nlm.nih.gov/39834030/). *Andrology*. [Review / Meta-Analysis]
Stamou M (2026). [PMID: 41765865](https://pubmed.ncbi.nlm.nih.gov/41765865/). *Genet Med*. [Gene Therapy / Novel Therapeutics]
Juul A (2026). [PMID: 41880614](https://pubmed.ncbi.nlm.nih.gov/41880614/). *N Engl J Med*. [Review / Meta-Analysis]
Graziani A (2026). [PMID: 40304702](https://pubmed.ncbi.nlm.nih.gov/40304702/). *Andrology*. [Review / Meta-Analysis]
Huijben M (2026). [PMID: 41987691](https://pubmed.ncbi.nlm.nih.gov/41987691/). *Andrology*. [Review / Meta-Analysis]
Miyake N (2026). [PMID: 41736118](https://pubmed.ncbi.nlm.nih.gov/41736118/). *Reprod Biol Endocrinol*. [Basic Science / Preclinical]
Campana C (2026). [PMID: 41638953](https://pubmed.ncbi.nlm.nih.gov/41638953/). *Best Pract Res Clin Endocrinol Metab*. [Review / Meta-Analysis]
Iglesias P (2026). [PMID: 42025349](https://pubmed.ncbi.nlm.nih.gov/42025349/). *Endocrinol Diabetes Nutr (Engl Ed)*. [Review / Meta-Analysis]
Nguyen H (2026). [PMID: 41839742](https://pubmed.ncbi.nlm.nih.gov/41839742/). *Clin Endocrinol (Oxf)*. [Epidemiology / Natural History]
AI-curated news mentioning hypogonadotropic hypogonadism
Updated Mar 20, 2026
A new study evaluates a co-designed website aimed at improving resources for congenital hypogonadotropic hypogonadism. This initiative highlights the importance of patient involvement in developing educational tools for rare diseases.