LHB encodes luteinizing hormone subunit beta (141 aa). Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids Highest expression in Pituitary (3,094 TPM) and Testis (8.6 TPM).

Hypogonadotropic hypogonadism 23 with or without anosmia is associated with mutations in the LHB gene on chromosome 19.

LHB is classified as a druggable target (Druggable Genome and Hormone Activity categories) with score 0.0.

Genetic testing for LHB is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hypogonadotropic hypogonadism 23 with or without anosmia has been reported in the published literature.

Phenotype severity distribution: 8 always present features, 1 common feature.

No clinical trials have been registered for hypogonadotropic hypogonadism 23 with or without anosmia.

202 publications have been identified in PubMed for hypogonadotropic hypogonadism 23 with or without anosmia. Kisho has analyzed 129 by research type. Research spans Review / Meta-Analysis (39%), Clinical Trial Publication (18%), and Epidemiology / Natural History (18%).

Recent Publications

• Sonne J (2026). [PMID: 30855798](https://pubmed.ncbi.nlm.nih.gov/30855798/). *Unknown Journal*. [Review / Meta-Analysis]

• Jokiranta ST (2026). [PMID: 40915391](https://pubmed.ncbi.nlm.nih.gov/40915391/). *Immunol Lett*. [Epidemiology / Natural History]

• Mullol J (2026). [PMID: 41493192](https://pubmed.ncbi.nlm.nih.gov/41493192/). *Int Forum Allergy Rhinol*. [Clinical Trial Publication]

• Bove R (2026). [PMID: 41766753](https://pubmed.ncbi.nlm.nih.gov/41766753/). *Neurol Clin Pract*. [Review / Meta-Analysis]

• Lubis JYG (2026). [PMID: 42111331](https://pubmed.ncbi.nlm.nih.gov/42111331/). *Int J Womens Health*. [Case Report / Case Series]

• Obiefuna S (2026). [PMID: 32119409](https://pubmed.ncbi.nlm.nih.gov/32119409/). *Unknown Journal*. [Epidemiology / Natural History]

• Li X (2026). [PMID: 29489163](https://pubmed.ncbi.nlm.nih.gov/29489163/). *Unknown Journal*. [Clinical Trial Publication]

• Liu R (2026). [PMID: 42116594](https://pubmed.ncbi.nlm.nih.gov/42116594/). *J Gerontol A Biol Sci Med Sci*. [Epidemiology / Natural History]

• Chiodini I (2026). [PMID: 42095177](https://pubmed.ncbi.nlm.nih.gov/42095177/). *Front Endocrinol (Lausanne)*. [Review / Meta-Analysis]

• Bal DS (2026). [PMID: 41168375](https://pubmed.ncbi.nlm.nih.gov/41168375/). *J Sex Med*. [Diagnostic / Biomarker]