Features include always present findings: Micropenis, Gonadotropin-releasing hormone deficiency, Anosmia, and Decreased serum testosterone concentration and others.

NDNF encodes neuron derived neurotrophic factor (568 aa). Secretory protein that plays a role in various cellular processes. Highest expression in Lung (44.6 TPM) and Ovary (32.4 TPM).

Hypogonadotropic hypogonadism 25 with anosmia is associated with mutations in the NDNF gene on chromosome 4.

NDNF is classified as a druggable target (Druggable Genome category) with score 0.0.

Genetic testing for NDNF is available. Testing is considered confirmatory for diagnosis.

Phenotype severity distribution: 8 always present features.

No clinical trials have been registered for hypogonadotropic hypogonadism 25 with anosmia.

4 publications have been identified in PubMed for hypogonadotropic hypogonadism 25 with anosmia. Research spans Case Report / Case Series (75%) and Review / Meta-Analysis (25%).

Recent Publications

• Lubis JYG (2026). [PMID: 42111331](https://pubmed.ncbi.nlm.nih.gov/42111331/). *Int J Womens Health*. [Case Report / Case Series]

• Rey RA (2025). [PMID: 41312956](https://pubmed.ncbi.nlm.nih.gov/41312956/). *Archives of endocrinology and metabolism*. [Review / Meta-Analysis]

• Soejima Y (2025). [PMID: 40141355](https://pubmed.ncbi.nlm.nih.gov/40141355/). *International journal of molecular sciences*. [Case Report / Case Series]

• Carriço JN (2024). [PMID: 39596130](https://pubmed.ncbi.nlm.nih.gov/39596130/). *International journal of molecular sciences*. [Case Report / Case Series]