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isolated hereditary congenital facial paralysis (HCFP) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

isolated hereditary congenital facial paralysis

MONDO:0011090

Also known as:HCFPMBS2 (formerly)Mobius syndrome 2 (formerly)

Find Clinical TrialsTrials

Overview

Isolated hereditary congenital facial paralysis (IHCFP) is an extremely rare neurological disorder presumed to result from maldevelopment of the facial nucleus and/or cranial nerve and has been reported in fewer than 10 families to date. It manifests as non-progressive, isolated, unilateral or bilateral, symmetrical or asymmetrical facial palsy. Involvement of the branches of the facial nerve can be unequal.

Clinical Trials1 registered · 1 recruiting

ResearchLimited published research (3 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

3 publications have been identified in PubMed for isolated hereditary congenital facial paralysis. Research spans Case Report / Case Series (67%) and Epidemiology / Natural History (33%).

Recent Publications

Agarwal R (2025). [PMID: 40171366](https://pubmed.ncbi.nlm.nih.gov/40171366/). *Cureus*. [Case Report / Case Series]
Liberton DK (2024). [PMID: 38791829](https://pubmed.ncbi.nlm.nih.gov/38791829/). *Int J Environ Res Public Health*. [Epidemiology / Natural History]
Alagappan A (2024). [PMID: 38910704](https://pubmed.ncbi.nlm.nih.gov/38910704/). *Cureus*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 8:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:306527

GARD

Genetic and Rare Diseases Info Center

GARD:8583

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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isolated hereditary congenital facial paralysis

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team