Features include: Diarrhea, Decreased small intestinal mucosa lactase level, Flatulence, and Lactose intolerance and 1 more.

MCM6 encodes minichromosome maintenance complex component 6 (821 aa). Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Highest expression in Cells EBV-transformed lymphocytes (88.0 TPM) and Cells Cultured fibroblasts (42.2 TPM).

Lactose intolerance adult type is associated with mutations in the MCM6 gene on chromosome 2.

The MCM6 protein participates in MCM4, MCM6 and MCM7 form a heterotrimer, Mcm4,6,7 trimer forms and associates with the replication fork, and CDT1-mediated loading of MCM2-7 to replication origins pathways.

MCM6 is classified as a druggable target (Enzyme and Kinase categories) with score 0.0.

Genetic testing for MCM6 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for lactose intolerance adult type has been reported in the published literature.

2 clinical trials registered. Interventions under study include other interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

35 publications have been identified in PubMed for lactose intolerance adult type. Research spans Basic Science / Preclinical (29%), Review / Meta-Analysis (20%), and Clinical Trial Publication (20%).