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Langerhans cell histiocytosis that occurs during adulthood.
33 clinical trials registered, 18 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 3 PHASE3, 22 PHASE2, 2 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT02670707](https://clinicaltrials.gov/study/NCT02670707) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 5:35 PM UTC
European rare disease database
Common questions about Langerhans cell histiocytosis specific to adulthood
Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH) |
PHASE3 |
Baylor College of Medicine |
RECRUITING |
[NCT07022834](https://clinicaltrials.gov/study/NCT07022834) | Real-world Study of Darafenib or Trametinib and Clofarabine for High-risk/Recurrent/Refractory Langerhans Cell Histiocytosis in Children | PHASE2 | West China Second University Hospital | RECRUITING |
[NCT07431060](https://clinicaltrials.gov/study/NCT07431060) | Modified LCH-III Regimen With or Without Luvometinib for Multisystem Pediatric Langerhans Cell Histiocytosis | NA | West China Second University Hospital | RECRUITING |
[NCT05997602](https://clinicaltrials.gov/study/NCT05997602) | To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH | PHASE2 | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | RECRUITING |
[NCT07371182](https://clinicaltrials.gov/study/NCT07371182) | Luvometinib in Pediatric SS-LCH With Special-site Single/Multifocal Bone Lesions | NA | West China Second University Hospital | RECRUITING |
111 publications have been identified in PubMed for Langerhans cell histiocytosis specific to adulthood. Kisho has analyzed 27 by research type. Research spans Review / Meta-Analysis (56%), Case Report / Case Series (19%), and Other (11%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 15 | 56% |
Patient case studies | 5 | 19% |
Other research | 3 | 11% |
Disease patterns and progression | 3 | 11% |
Clinical study results | 1 | 4% |
Sathish K (2026). [PMID: 42130999](https://pubmed.ncbi.nlm.nih.gov/42130999/). *J Orthop Case Rep*. [Case Report / Case Series]
Rech KL (2026). [PMID: 41651609](https://pubmed.ncbi.nlm.nih.gov/41651609/). *Surg Pathol Clin*. [Review / Meta-Analysis]
Harari S (2026). [PMID: 42167770](https://pubmed.ncbi.nlm.nih.gov/42167770/). *Eur Respir J*. [Other]
Keehan L (2026). [PMID: 41174928](https://pubmed.ncbi.nlm.nih.gov/41174928/). *Am J Med Genet A*. [Review / Meta-Analysis]
Tillotson CV (2026). [PMID: 28613635](https://pubmed.ncbi.nlm.nih.gov/28613635/). *Unknown Journal*. [Review / Meta-Analysis]
De Mori LH (2025). [PMID: 40974043](https://pubmed.ncbi.nlm.nih.gov/40974043/). *Expert Rev Clin Immunol*. [Review / Meta-Analysis]
Franciosi AN (2025). [PMID: 39168181](https://pubmed.ncbi.nlm.nih.gov/39168181/). *Chest*. [Review / Meta-Analysis]
Hamoud M (2025). [PMID: 40377406](https://pubmed.ncbi.nlm.nih.gov/40377406/). *Expert Opin Pharmacother*. [Other]
Lin H (2025). [PMID: 39428688](https://pubmed.ncbi.nlm.nih.gov/39428688/). *Br J Haematol*. [Clinical Trial Publication]
Savithri V (2025). [PMID: 40279049](https://pubmed.ncbi.nlm.nih.gov/40279049/). *Head Neck Pathol*. [Case Report / Case Series]
AI-curated news mentioning Langerhans cell histiocytosis specific to adulthood
Updated Sep 18, 2026
A recent case report highlights the use of contrast-enhanced sonography for diagnosing Langerhans cell hyperplasia in children with isolated liver involvement. This study contributes to the understanding of imaging techniques in rare pediatric liver diseases.
A Canadian multicenter case series investigates Langerhans cell histiocytosis in adults, providing new insights into its clinical presentation and management. This study contributes to the understanding of this rare disease, which may inform future research and treatment strategies.
A recent study highlights the complexities of diagnosing multifocal Langerhans cell histiocytosis, particularly when it involves the thyroid and multiple organs. This research underscores the need for heightened awareness and improved diagnostic strategies for this rare condition.