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A neoplastic proliferation of Langerhans cells with overtly malignant cytologic features. It can be considered a higher grade variant of Langerhans cell histiocytosis (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001)
Biomarker and diagnostic research for Langerhans cell sarcoma has been reported in the published literature.
No clinical trials have been registered for Langerhans cell sarcoma.
63 publications have been identified in PubMed for Langerhans cell sarcoma. Research spans Case Report / Case Series (37%), Basic Science / Preclinical (21%), and Review / Meta-Analysis (16%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 23 | 37% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 1:32 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Langerhans cell sarcoma
13 |
21% |
Research summaries | 10 | 16% |
Testing and diagnosis research | 8 | 13% |
Disease patterns and progression | 4 | 6% |
Other research | 2 | 3% |
New treatment approaches | 2 | 3% |
Clinical study results | 1 | 2% |
Ermakov MS (2026). [PMID: 42092301](https://pubmed.ncbi.nlm.nih.gov/42092301/). *J Pathol*. [Basic Science / Preclinical]
Chen QQ (2026). [PMID: 41264975](https://pubmed.ncbi.nlm.nih.gov/41264975/). *Annals of diagnostic pathology*. [Case Report / Case Series]
Tsipou H (2026). [PMID: 41835761](https://pubmed.ncbi.nlm.nih.gov/41835761/). *Cureus*. [Case Report / Case Series]
Okuguchi H (2026). [PMID: 41841633](https://pubmed.ncbi.nlm.nih.gov/41841633/). *The Journal of dermatology*. [Clinical Trial Publication]
Largeaud L (2026). [PMID: 41798885](https://pubmed.ncbi.nlm.nih.gov/41798885/). *EJHaem*. [Case Report / Case Series]
Ladak NN (2026). [PMID: 41749512](https://pubmed.ncbi.nlm.nih.gov/41749512/). *Histopathology*. [Basic Science / Preclinical]
Soares Costa T (2026). [PMID: 41841069](https://pubmed.ncbi.nlm.nih.gov/41841069/). *Cureus*. [Basic Science / Preclinical]
Lang M (2026). [PMID: 41559709](https://pubmed.ncbi.nlm.nih.gov/41559709/). *Orphanet journal of rare diseases*. [Epidemiology / Natural History]
Bagrecha M (2026). [PMID: 41741123](https://pubmed.ncbi.nlm.nih.gov/41741123/). *BMJ case reports*. [Case Report / Case Series]
Alvarez-Lesmes J (2026). [PMID: 40831220](https://pubmed.ncbi.nlm.nih.gov/40831220/). *International journal of surgical pathology*. [Basic Science / Preclinical]