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Laryngo-tracheo-esophageal cleft (LC) type 3 is a congenital respiratory tract anomaly characterized by a cleft extending through the cricoid cartilage, sometimes into the cervical trachea, with severe swallowing disorders, lung infections and pulmonary damage.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for laryngotracheoesophageal cleft type 3.
11 publications have been identified in PubMed for laryngotracheoesophageal cleft type 3. Research spans Clinical Trial Publication (36%), Case Report / Case Series (27%), and Review / Meta-Analysis (18%).
Research Type | Count | % of Total |
|---|---|---|
Clinical study results | 4 | 36% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 5:21 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Patient case studies
3 |
27% |
Research summaries | 2 | 18% |
Disease patterns and progression | 2 | 18% |
Gyawali BR (2026). [PMID: 41879087](https://pubmed.ncbi.nlm.nih.gov/41879087/). *Ear Nose Throat J*. [Review / Meta-Analysis]
Ferroul F (2025). [PMID: 41005613](https://pubmed.ncbi.nlm.nih.gov/41005613/). *Eur J Med Genet*. [Case Report / Case Series]
O'Riordan I (2025). [PMID: 40579891](https://pubmed.ncbi.nlm.nih.gov/40579891/). *Laryngoscope*. [Clinical Trial Publication]
Awad BI (2025). [PMID: 40330935](https://pubmed.ncbi.nlm.nih.gov/40330935/). *AME Case Rep*. [Case Report / Case Series]
Li Q (2025). [PMID: 39924319](https://pubmed.ncbi.nlm.nih.gov/39924319/). *Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi*. [Clinical Trial Publication]
Wang Y (2025). [PMID: 41331794](https://pubmed.ncbi.nlm.nih.gov/41331794/). *BMC Cardiovasc Disord*. [Review / Meta-Analysis]
Francisco S (2025). [PMID: 40227884](https://pubmed.ncbi.nlm.nih.gov/40227884/). *Laryngoscope*. [Epidemiology / Natural History]
Virani FR (2025). [PMID: 40570586](https://pubmed.ncbi.nlm.nih.gov/40570586/). *Int J Pediatr Otorhinolaryngol*. [Epidemiology / Natural History]
Jin W (2025). [PMID: 39759945](https://pubmed.ncbi.nlm.nih.gov/39759945/). *OTO Open*. [Case Report / Case Series]
Worden CP (2024). [PMID: 38488232](https://pubmed.ncbi.nlm.nih.gov/38488232/). *Otolaryngol Head Neck Surg*. [Clinical Trial Publication]