Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

laryngotracheoesophageal cleft type 4 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

laryngotracheoesophageal cleft type 4

MONDO:0019764

Also known as:LTEC IVLTEC4laryngo-tracheo-esophageal cleft type 4

Overview

Laryngo-tracheo-esophageal cleft (LC) type 4 is a serious congenital respiratory tract anomaly characterized by a cleft extending into the thoracic trachea and possibly down to the carina, with respiratory distress.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Difficulty breathing (respiratory insufficiency), Abnormal form of the vertebral bodies, and Cachexia; and common findings: Abnormal rib morphology, Laryngomalacia, Abnormal cardiac septum morphology, and Spleen abnormalities (abnormality of the spleen) and others.

Organ System	Phenotype Count	Example Features
Digestive system	2	Spleen abnormalities (abnormality of the spleen), Intestinal atresia

Prognosis

Phenotype severity distribution: 3 very common features, 9 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for laryngotracheoesophageal cleft type 4.

12 publications have been identified in PubMed for laryngotracheoesophageal cleft type 4. Research spans Clinical Trial Publication (42%), Case Report / Case Series (33%), and Epidemiology / Natural History (17%).

Research Type	Count	% of Total
Clinical study results	5	42%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:41 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:93941

GARD

Genetic and Rare Diseases Info Center

GARD:19238

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

laryngotracheoesophageal cleft type 4

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

laryngotracheoesophageal cleft type 4

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications