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An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells.
Biomarker and diagnostic research for leiomyosarcoma of the corpus uteri has been reported in the published literature.
9 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, procedural interventions, and other interventions. Pipeline includes 7 PHASE2, 1 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04727242](https://clinicaltrials.gov/study/NCT04727242) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 6:15 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma |
PHASE2 |
Stanford University |
UNKNOWN |
[NCT05649956](https://clinicaltrials.gov/study/NCT05649956) | Letrozole in Uterine Leiomyosarcoma | PHASE2 | GOG Foundation | RECRUITING |
[NCT07076186](https://clinicaltrials.gov/study/NCT07076186) | Phase II Decentralized Pragmatic Trial of Adjuvant Doxorubicin - Trabectedin Chemotherapy in uLMS | PHASE2 | M.D. Anderson Cancer Center | RECRUITING |
[NCT04200443](https://clinicaltrials.gov/study/NCT04200443) | Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma | PHASE2 | City of Hope Medical Center | ACTIVE_NOT_RECRUITING |
[NCT01793168](https://clinicaltrials.gov/study/NCT01793168) | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | — | Sanford Health | RECRUITING |
118 publications have been identified in PubMed for leiomyosarcoma of the corpus uteri. Research spans Case Report / Case Series (33%), Review / Meta-Analysis (19%), and Basic Science / Preclinical (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 39 | 33% |
Research summaries | 23 | 19% |
Laboratory research | 17 | 14% |
Testing and diagnosis research | 16 | 14% |
Disease patterns and progression | 10 | 8% |
Clinical study results | 5 | 4% |
New treatment approaches | 5 | 4% |
Other research | 3 | 3% |
Toyoshima M (2026). [PMID: 41513280](https://pubmed.ncbi.nlm.nih.gov/41513280/). *BMJ Case Rep*. [Case Report / Case Series]
Zhou FL (2026). [PMID: 42252304](https://pubmed.ncbi.nlm.nih.gov/42252304/). *Acta Pharmacol Sin*. [Basic Science / Preclinical]
Gao X (2026). [PMID: 41639854](https://pubmed.ncbi.nlm.nih.gov/41639854/). *BMC Womens Health*. [Case Report / Case Series]
Cambrelin A (2026). [PMID: 41993872](https://pubmed.ncbi.nlm.nih.gov/41993872/). *Case Rep Oncol Med*. [Case Report / Case Series]
Komura N (2026). [PMID: 41455452](https://pubmed.ncbi.nlm.nih.gov/41455452/). *Int J Gynecol Cancer*. [Basic Science / Preclinical]
Chiang S (2026). [PMID: 41086256](https://pubmed.ncbi.nlm.nih.gov/41086256/). *Annu Rev Pathol*. [Review / Meta-Analysis]
Nagao Y (2026). [PMID: 41588380](https://pubmed.ncbi.nlm.nih.gov/41588380/). *BMC Cancer*. [Epidemiology / Natural History]
Lin M (2026). [PMID: 42116313](https://pubmed.ncbi.nlm.nih.gov/42116313/). *Medicine (Baltimore)*. [Case Report / Case Series]
Rehman A (2026). [PMID: 41396183](https://pubmed.ncbi.nlm.nih.gov/41396183/). *Int J Gynecol Pathol*. [Basic Science / Preclinical]
Pilkington T (2026). [PMID: 41369044](https://pubmed.ncbi.nlm.nih.gov/41369044/). *Am J Surg Pathol*. [Case Report / Case Series]