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Loeffler's endocarditis is a rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma.
Biomarker and diagnostic research for Loeffler endocarditis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for Loeffler endocarditis.
26 publications have been identified in PubMed for Loeffler endocarditis. Research spans Case Report / Case Series (81%), Diagnostic / Biomarker (8%), and Review / Meta-Analysis (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 21 | 81% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Loeffler endocarditis
2 |
8% |
Research summaries | 2 | 8% |
Disease patterns and progression | 1 | 4% |
Contreras-Yametti FI (2026). [PMID: 42093632](https://pubmed.ncbi.nlm.nih.gov/42093632/). *Circ Cardiovasc Imaging*. [Diagnostic / Biomarker]
Nardin M (2026). [PMID: 41738410](https://pubmed.ncbi.nlm.nih.gov/41738410/). *Giornale italiano di cardiologia (2006)*. [Case Report / Case Series]
Malikides O (2026). [PMID: 41403213](https://pubmed.ncbi.nlm.nih.gov/41403213/). *Future cardiology*. [Case Report / Case Series]
Serrano-Marcos JM (2026). [PMID: 40967569](https://pubmed.ncbi.nlm.nih.gov/40967569/). *Revista espanola de cardiologia (English ed.)*. [Case Report / Case Series]
Chen P (2025). [PMID: 40426268](https://pubmed.ncbi.nlm.nih.gov/40426268/). *Journal of cardiothoracic surgery*. [Review / Meta-Analysis]
Miyazaki J (2025). [PMID: 40490583](https://pubmed.ncbi.nlm.nih.gov/40490583/). *Journal of medical ultrasonics (2001)*. [Case Report / Case Series]
Ye Y (2025). [PMID: 40235747](https://pubmed.ncbi.nlm.nih.gov/40235747/). *Quantitative imaging in medicine and surgery*. [Case Report / Case Series]
Kawano H (2025). [PMID: 40399090](https://pubmed.ncbi.nlm.nih.gov/40399090/). *Internal medicine (Tokyo, Japan)*. [Case Report / Case Series]
Wan X (2025). [PMID: 41460281](https://pubmed.ncbi.nlm.nih.gov/41460281/). *Journal of echocardiography*. [Diagnostic / Biomarker]
Schultz HM (2025). [PMID: 40904761](https://pubmed.ncbi.nlm.nih.gov/40904761/). *Journal of medical cases*. [Case Report / Case Series]