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Tropical endomyocardial fibrosis is a restrictive cardiopathy, occurring almost exclusively in children and young adults in tropical and subtropical regions, characterized by endocardial fibrosis, affecting the apices and the inflow tract of the right or left ventricle (or both) and manifesting with a restrictive cardimyopathy and atrioventricular regurgitation leading to severe pulmonary hypertension, very high systemic venous pressure and congestive cardiac failure. Suspected etiologies include helminth and protozoal infestation and malnutrition.
Biomarker and diagnostic research for tropical endomyocardial fibrosis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for tropical endomyocardial fibrosis.
7 publications have been identified in PubMed for tropical endomyocardial fibrosis. Research spans Review / Meta-Analysis (43%), Case Report / Case Series (43%), and Diagnostic / Biomarker (14%).
Bhatti K (2026). [PMID: 30020665](https://pubmed.ncbi.nlm.nih.gov/30020665/). *Unknown Journal*. [Review / Meta-Analysis]
Adhikari S (2025). [PMID: 41399600](https://pubmed.ncbi.nlm.nih.gov/41399600/). *Cureus*. [Review / Meta-Analysis]
Segulin B (2025). [PMID: 41348095](https://pubmed.ncbi.nlm.nih.gov/41348095/). *European heart journal. Cardiovascular Imaging*. [Diagnostic / Biomarker]
Mocumbi AO (2025). [PMID: 40011660](https://pubmed.ncbi.nlm.nih.gov/40011660/). *Nature reviews. Cardiology*. [Review / Meta-Analysis]
Tapia Martínez M (2025). [PMID: 41377797](https://pubmed.ncbi.nlm.nih.gov/41377797/). *European journal of case reports in internal medicine*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 8:30 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Cooke H (2024). [PMID: 41846857](https://pubmed.ncbi.nlm.nih.gov/41846857/). *Br J Cardiol*. [Case Report / Case Series]
López Gutiérrez LV (2024). [PMID: 40401032](https://pubmed.ncbi.nlm.nih.gov/40401032/). *Archivos peruanos de cardiologia y cirugia cardiovascular*. [Case Report / Case Series]