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macroglossia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

macroglossia

MONDO:0015496

Also known as:enlarged tonguegiant tongue

Overview

The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)

Diagnosis

Biomarker and diagnostic research for macroglossia has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for macroglossia.

126 publications have been identified in PubMed for macroglossia. Kisho has analyzed 16 by research type. Research spans Review / Meta-Analysis (63%), Case Report / Case Series (19%), and Diagnostic / Biomarker (6%).

Research Type	Count	% of Total
Research summaries	10	63%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:49 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:156207

GARD

Genetic and Rare Diseases Info Center

GARD:3342

Questions for Your Care Team

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macroglossia

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications