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A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma.
Biomarker and diagnostic research for malignant germ cell tumor has been reported in the published literature.
17 clinical trials registered, 5 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 2 PHASE3, 12 PHASE2, 3 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05969860](https://clinicaltrials.gov/study/NCT05969860) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 7:49 AM UTC
Genetic and Rare Diseases Info Center
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer |
PHASE2 |
Mayo Clinic |
RECRUITING |
[NCT07218913](https://clinicaltrials.gov/study/NCT07218913) | Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors | PHASE1 | City of Hope Medical Center | RECRUITING |
[NCT04901702](https://clinicaltrials.gov/study/NCT04901702) | Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma | PHASE1 | St. Jude Children's Research Hospital | RECRUITING |
[NCT05857969](https://clinicaltrials.gov/study/NCT05857969) | Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling | PHASE1 | Florida International University | RECRUITING |
[NCT06418789](https://clinicaltrials.gov/study/NCT06418789) | High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors | PHASE2 | N.N. Petrov National Medical Research Center of Oncology | RECRUITING |
264 publications have been identified in PubMed for malignant germ cell tumor. Kisho has analyzed 149 by research type. Research spans Review / Meta-Analysis (32%), Basic Science / Preclinical (28%), and Case Report / Case Series (19%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 47 | 32% |
Laboratory research | 42 | 28% |
Patient case studies | 29 | 19% |
Disease patterns and progression | 13 | 9% |
Clinical study results | 6 | 4% |
Testing and diagnosis research | 5 | 3% |
New treatment approaches | 4 | 3% |
Other research | 3 | 2% |
Jiao YY (2026). [PMID: 41958928](https://pubmed.ncbi.nlm.nih.gov/41958928/). *Front Pharmacol*. [Case Report / Case Series]
Yang W (2026). [PMID: 40995674](https://pubmed.ncbi.nlm.nih.gov/40995674/). *Pharmacogenet Genomics*. [Clinical Trial Publication]
Parteni DE (2026). [PMID: 42192914](https://pubmed.ncbi.nlm.nih.gov/42192914/). *Cancers (Basel)*. [Review / Meta-Analysis]
Rogalidou M (2026). [PMID: 41562819](https://pubmed.ncbi.nlm.nih.gov/41562819/). *Reports (MDPI)*. [Case Report / Case Series]
Di Costanzo F (2026). [PMID: 40494333](https://pubmed.ncbi.nlm.nih.gov/40494333/). *Oncol Res Treat*. [Review / Meta-Analysis]
Bach EA (2026). [PMID: 42097810](https://pubmed.ncbi.nlm.nih.gov/42097810/). *Curr Top Dev Biol*. [Review / Meta-Analysis]
Zeng C (2026). [PMID: 41513691](https://pubmed.ncbi.nlm.nih.gov/41513691/). *Nat Commun*. [Basic Science / Preclinical]
Liu P (2026). [PMID: 41455287](https://pubmed.ncbi.nlm.nih.gov/41455287/). *European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology*. [Gene Therapy / Novel Therapeutics]
Ramya Lakshmi KV (2026). [PMID: 42110050](https://pubmed.ncbi.nlm.nih.gov/42110050/). *Cureus*. [Case Report / Case Series]
Moody SC (2026). [PMID: 40693358](https://pubmed.ncbi.nlm.nih.gov/40693358/). *Andrology*. [Epidemiology / Natural History]