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Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include confusion; hallucinations; and an extrapyramidal syndrome (Parkinson disease, secondary) that includes rigidity; dystonia; retropulsion; and tremor. (Adams, Principles of Neurology, 6th ed, p1213)
Biomarker and diagnostic research for manganese poisoning has been reported in the published literature.
No approved treatments are currently available for manganese poisoning. An additional 1 compound holds orphan drug designation.
While no drugs are FDA-approved specifically for manganese poisoning, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for manganese poisoning. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
No clinical trials have been registered for manganese poisoning.
53 publications have been identified in PubMed for manganese poisoning. Research spans Basic Science / Preclinical (55%), Review / Meta-Analysis (17%), and Case Report / Case Series (13%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 29 | 55% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:39 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Designated
Exclusivity End |
|---|
Designation Status |
|---|
trientine hydrochloride | trientine hydrochloride | Cerberus Princeton, LLC | 2010 | — | Designated |
Gene therapy approaches for manganese poisoning have been reported in the published literature.
View trials for manganese poisoning
9 |
17% |
Patient case studies | 7 | 13% |
Testing and diagnosis research | 3 | 6% |
Clinical study results | 2 | 4% |
Other research | 1 | 2% |
Disease patterns and progression | 1 | 2% |
New treatment approaches | 1 | 2% |
Evans GR (2026). [PMID: 32809738](https://pubmed.ncbi.nlm.nih.gov/32809738/). *Unknown Journal*. [Review / Meta-Analysis]
Wu J (2026). [PMID: 41865917](https://pubmed.ncbi.nlm.nih.gov/41865917/). *Neuroimage*. [Diagnostic / Biomarker]
Mendez-Vazquez H (2026). [PMID: 42167917](https://pubmed.ncbi.nlm.nih.gov/42167917/). *J Neurosci*. [Basic Science / Preclinical]
Kruer MC (2026). [PMID: 41133294](https://pubmed.ncbi.nlm.nih.gov/41133294/). *Movement disorders : official journal of the Movement Disorder Society*. [Basic Science / Preclinical]
Akkale T (2026). [PMID: 41679656](https://pubmed.ncbi.nlm.nih.gov/41679656/). *Neurotoxicology*. [Basic Science / Preclinical]
Pefferkorn E (2025). [PMID: 38951377](https://pubmed.ncbi.nlm.nih.gov/38951377/). *Forensic science, medicine, and pathology*. [Case Report / Case Series]
Hong H (2025). [PMID: 39847159](https://pubmed.ncbi.nlm.nih.gov/39847159/). *Cell biology and toxicology*. [Basic Science / Preclinical]
Wang J (2025). [PMID: 41094656](https://pubmed.ncbi.nlm.nih.gov/41094656/). *Molecular cancer*. [Basic Science / Preclinical]
Harifi H (2025). [PMID: 40934862](https://pubmed.ncbi.nlm.nih.gov/40934862/). *Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)*. [Basic Science / Preclinical]
Digman A (2025). [PMID: 40280417](https://pubmed.ncbi.nlm.nih.gov/40280417/). *The Journal of biological chemistry*. [Basic Science / Preclinical]