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Cyanide-induced parkinsonism is a rare parkinsonian syndrome due to intoxication which develops in individuals surviving an acute cyanide intoxication episode or due to chronic exposure to small cyanide doses. It presents several weeks after acute exposure with progressive typical clinical features of parkinsonism including bradykinesia, rigidity, dystonia, hypomimia, hypokinetic dysarthria, postural instability and retropulsion but no resting or postural tremor. Brain MRI reveals bilateral lesions in the pallidum, posterior putamen, substantia nigra, subthalamic nucleus, temporal and occipital cortex, and cerebellum.
Biomarker and diagnostic research for cyanide-induced parkinsonism has been reported in the published literature.
No clinical trials have been registered for cyanide-induced parkinsonism.
3 publications have been identified in PubMed for cyanide-induced parkinsonism. Research spans Diagnostic / Biomarker (33%), Basic Science / Preclinical (33%), and Epidemiology / Natural History (33%).
Marchi E (2026). [PMID: 41746958](https://pubmed.ncbi.nlm.nih.gov/41746958/). *PloS one*. [Epidemiology / Natural History]
Baninameh Z (2025). [PMID: 39912496](https://pubmed.ncbi.nlm.nih.gov/39912496/). *Autophagy*. [Diagnostic / Biomarker]
Bi PY (2024). [PMID: 38555279](https://pubmed.ncbi.nlm.nih.gov/38555279/). *Communications biology*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:55 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center