GCK encodes glucokinase (465 aa). Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Highest expression in Pituitary (34.5 TPM) and Brain Cerebellar Hemisphere (7.2 TPM).

Maturity-onset diabetes of the young type 2 is associated with mutations in the GCK gene on chromosome 7.

GCK is classified as a druggable target (Druggable Genome, Enzyme, and Kinase categories) with score 6.5.

Genetic testing for GCK is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for maturity-onset diabetes of the young type 2 has been reported in the published literature.

Phenotype severity distribution: 1 always present feature.

2 clinical trials registered, 1 recruiting. Interventions under study include drug therapy, procedural interventions, and biologic therapy. Pipeline includes 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

118 publications have been identified in PubMed for maturity-onset diabetes of the young type 2. Research spans Case Report / Case Series (26%), Basic Science / Preclinical (21%), and Review / Meta-Analysis (20%).

Recent Publications

• Fatani TH (2026). [PMID: 41772505](https://pubmed.ncbi.nlm.nih.gov/41772505/). *BMC Pediatr*. [Case Report / Case Series]

• Lin J (2026). [PMID: 42155026](https://pubmed.ncbi.nlm.nih.gov/42155026/). *QJM*. [Case Report / Case Series]

• Expósito García M (2026). [PMID: 41670436](https://pubmed.ncbi.nlm.nih.gov/41670436/). *J Endocrinol*. [Basic Science / Preclinical]

• Harvengt A (2026). [PMID: 41827917](https://pubmed.ncbi.nlm.nih.gov/41827917/). *Cells*. [Epidemiology / Natural History]

• Louvet I (2026). [PMID: 42100870](https://pubmed.ncbi.nlm.nih.gov/42100870/). *JCI Insight*. [Basic Science / Preclinical]

• Laver TW (2026). [PMID: 41772234](https://pubmed.ncbi.nlm.nih.gov/41772234/). *Diabetologia*. [Review / Meta-Analysis]

• Sharma PP (2026). [PMID: 41938311](https://pubmed.ncbi.nlm.nih.gov/41938311/). *AACE Endocrinol Diabetes*. [Case Report / Case Series]

• Sharp LN (2026). [PMID: 41175096](https://pubmed.ncbi.nlm.nih.gov/41175096/). *J Clin Endocrinol Metab*. [Epidemiology / Natural History]

• Arosemena M (2026). [PMID: 41232044](https://pubmed.ncbi.nlm.nih.gov/41232044/). *Diabetes*. [Clinical Trial Publication]

• Slaoui K (2026). [PMID: 41307241](https://pubmed.ncbi.nlm.nih.gov/41307241/). *J Biomol Struct Dyn*. [Basic Science / Preclinical]