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maturity-onset diabetes of the young type 7 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

maturity-onset diabetes of the young type 7

MONDO:0012513

Also known as:KLF11 maturity-onset diabetes of the young (disease)MODY7maturity-onset diabetes of the young (disease) caused by mutation in KLF11

Overview

Any maturity-onset diabetes of the young in which the cause of the disease is a mutation in the KLF11 gene.

GeneticsAutosomal dominant · KLF11 (chr 2)

ResearchLimited published research (5 articles)

Clinical Presentation

Features include: Maturity-onset diabetes of the young and Type II diabetes mellitus.

Organ System	Phenotype Count	Example Features
Hormones	2	Maturity-onset diabetes of the young, Type II diabetes mellitus

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

KLF11 encodes KLF transcription factor 11 (512 aa). Transcription factor. Highest expression in Testis (43.7 TPM) and Adipose Subcutaneous (42.3 TPM).

Maturity-onset diabetes of the young type 7 is associated with mutations in the KLF11 gene on chromosome 2.

KLF11 is classified as a druggable target (Transcription Factor category) with score 0.0.

Diagnosis

Genetic testing for KLF11 is available. Testing is considered confirmatory for diagnosis.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for maturity-onset diabetes of the young type 7.

5 publications have been identified in PubMed for maturity-onset diabetes of the young type 7. Research spans Case Report / Case Series (60%), Basic Science / Preclinical (20%), and Epidemiology / Natural History (20%).

Recent Publications

Qiao Y (2026). [PMID: 41890190](https://pubmed.ncbi.nlm.nih.gov/41890190/). *Front Endocrinol (Lausanne)*. [Case Report / Case Series]
Eser M (2025). [PMID: 39361122](https://pubmed.ncbi.nlm.nih.gov/39361122/). *J Appl Genet*. [Basic Science / Preclinical]
Alvarez M (2025). [PMID: 41278445](https://pubmed.ncbi.nlm.nih.gov/41278445/). *World J Diabetes*. [Case Report / Case Series]
Song L (2024). [PMID: 39193968](https://pubmed.ncbi.nlm.nih.gov/39193968/). *Clin Lab*. [Case Report / Case Series]
Özsu E (2024). [PMID: 38665000](https://pubmed.ncbi.nlm.nih.gov/38665000/). *J Clin Res Pediatr Endocrinol*. [Epidemiology / Natural History]

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 5:14 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:610508

GARD

Genetic and Rare Diseases Info Center

GARD:10661

Questions for Your Care Team

→Should I pursue genetic testing for KLF11, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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maturity-onset diabetes of the young type 7

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team