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median cleft of the upper lip and maxilla - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

median cleft of the upper lip and maxilla

MONDO:0015413

Overview

Median cleft of the upper lip and maxilla is a rare, congenital, developmental defect during embryogenesis characterized by a midline vertical cleft through the upper lip and premaillary bone (can also involve the nasal septum and central nervous system). The phenotypic spectrum is highly variable (ranging from a simple vermillion notch to a wide complete cleft) and hypo/hypertelorism, telecanthus, monophthalmia, flat or cleft nose, wide columella, median alveolar cleft and cranial malformations may be associated.

ResearchLimited published research (3 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for median cleft of the upper lip and maxilla.

3 publications have been identified in PubMed for median cleft of the upper lip and maxilla. Research spans Epidemiology / Natural History (67%) and Clinical Trial Publication (33%).

Recent Publications

Abd-El-Ghafour M (2025). [PMID: 40410786](https://pubmed.ncbi.nlm.nih.gov/40410786/). *BMC oral health*. [Epidemiology / Natural History]
Rando GM (2024). [PMID: 39062273](https://pubmed.ncbi.nlm.nih.gov/39062273/). *Children (Basel, Switzerland)*. [Clinical Trial Publication]
Novakova M (2024). [PMID: 39472868](https://pubmed.ncbi.nlm.nih.gov/39472868/). *BMC oral health*. [Epidemiology / Natural History]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 4:38 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:141239

GARD

Genetic and Rare Diseases Info Center

GARD:19966

Questions for Your Care Team

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median cleft of the upper lip and maxilla

Overview

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team