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midline cervical cleft - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

midline cervical cleft

MONDO:0015419

Overview

Midline cervical cleft (MCC) is a rare congenital anomaly characterized by the presence at birth of a vertical, atrophic and usually erythematous skin defect, lacking adnexal elements in the midline of the neck that may be attached to a subcutaneous fibrous cord of variable length; a superior skin tag; and an inferior, short (usually about 1 cm in length) sinus (possibly with presence of discharge). If untreated (by surgical removal) complications include restriction of neck extension due to contracture and scarring. It is sometimes associated with other developmental defects such as bifid mandible, thyroglossal duct and branchial cysts, and microgenia.

ResearchLimited published research (4 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for midline cervical cleft.

5 publications have been identified in PubMed for midline cervical cleft. Research spans Case Report / Case Series (75%) and Review / Meta-Analysis (25%).

Recent Publications

Hwang JC (2025). [PMID: 39403013](https://pubmed.ncbi.nlm.nih.gov/39403013/). *Cleft Palate Craniofac J*. [Case Report / Case Series]
Cajozzo M (2025). [PMID: 41189923](https://pubmed.ncbi.nlm.nih.gov/41189923/). *J Plast Reconstr Surg*. [Case Report / Case Series]
Adi G (2025). [PMID: 41122247](https://pubmed.ncbi.nlm.nih.gov/41122247/). *Front Surg*. [Case Report / Case Series]
Magalhães R (2024). [PMID: 38688177](https://pubmed.ncbi.nlm.nih.gov/38688177/). *J Plast Reconstr Aesthet Surg*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:28 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:141288

GARD

Genetic and Rare Diseases Info Center

GARD:19971

Questions for Your Care Team

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midline cervical cleft

Overview

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team