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A bacterial infection of the membranes covering the brain and the spinal cord caused by Mycobacterium tuberculosis.
Biomarker and diagnostic research for meningeal tuberculosis has been reported in the published literature.
6 clinical trials registered, 4 recruiting. Interventions under study include drug therapy. Pipeline includes 2 PHASE3, 3 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05383742](https://clinicaltrials.gov/study/NCT05383742) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 8:40 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
PHASE2 |
National Institute of Allergy and Infectious Diseases (NIAID) |
RECRUITING |
[NCT04145258](https://clinicaltrials.gov/study/NCT04145258) | Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis | PHASE3 | ANRS, Emerging Infectious Diseases | RECRUITING |
[NCT05590455](https://clinicaltrials.gov/study/NCT05590455) | Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis | PHASE2 | ANRS, Emerging Infectious Diseases | RECRUITING |
[NCT05917340](https://clinicaltrials.gov/study/NCT05917340) | Intensified Short Course Regimen for TBM in Adults | PHASE3 | Indian Council of Medical Research | NOT_YET_RECRUITING |
[NCT07227779](https://clinicaltrials.gov/study/NCT07227779) | B-PaLMZ for TB Meningitis | PHASE2 | David Boulware | RECRUITING |
117 publications have been identified in PubMed for meningeal tuberculosis. Research spans Case Report / Case Series (34%), Epidemiology / Natural History (21%), and Review / Meta-Analysis (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 40 | 34% |
Disease patterns and progression | 24 | 21% |
Research summaries | 15 | 13% |
Testing and diagnosis research | 14 | 12% |
Clinical study results | 11 | 9% |
Laboratory research | 10 | 9% |
New treatment approaches | 2 | 2% |
Other research | 1 | 1% |
Smith AD (2026). [PMID: 42022716](https://pubmed.ncbi.nlm.nih.gov/42022716/). *Cureus*. [Case Report / Case Series]
Thirion A (2026). [PMID: 42032016](https://pubmed.ncbi.nlm.nih.gov/42032016/). *Sci Rep*. [Diagnostic / Biomarker]
Figueiredo Dos Santos ACP (2026). [PMID: 41767987](https://pubmed.ncbi.nlm.nih.gov/41767987/). *Bulletin of the World Health Organization*. [Case Report / Case Series]
Adrizain R (2026). [PMID: 41514403](https://pubmed.ncbi.nlm.nih.gov/41514403/). *BMC infectious diseases*. [Case Report / Case Series]
Sotomayor-González A (2026). [PMID: 41970085](https://pubmed.ncbi.nlm.nih.gov/41970085/). *Cureus*. [Case Report / Case Series]
Dang MT (2026). [PMID: 41750734](https://pubmed.ncbi.nlm.nih.gov/41750734/). *Diagnostics (Basel, Switzerland)*. [Diagnostic / Biomarker]
Ponce LML (2026). [PMID: 41846668](https://pubmed.ncbi.nlm.nih.gov/41846668/). *Cureus*. [Epidemiology / Natural History]
Rahaman MZ (2026). [PMID: 41972019](https://pubmed.ncbi.nlm.nih.gov/41972019/). *Public Health Pract (Oxf)*. [Review / Meta-Analysis]
Ullah N (2026). [PMID: 41675892](https://pubmed.ncbi.nlm.nih.gov/41675892/). *Annals of medicine and surgery (2012)*. [Review / Meta-Analysis]
Dixit A (2026). [PMID: 41330436](https://pubmed.ncbi.nlm.nih.gov/41330436/). *Encephalitis (Seoul, Korea)*. [Clinical Trial Publication]