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A migraine disorder characterized by episodes that occur in the absence of preceding focal neurological symptoms.
Biomarker and diagnostic research for migraine without aura has been reported in the published literature.
19 clinical trials registered, 10 recruiting. Interventions under study include other interventions, drug therapy, and medical devices. Pipeline includes 1 PHASE3, 1 PHASE2, 2 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05987592](https://clinicaltrials.gov/study/NCT05987592) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:58 AM UTC
BE WELL With Migraine: Brain Education and WELLness With Migraine |
NA |
Wake Forest University Health Sciences |
RECRUITING |
[NCT06409832](https://clinicaltrials.gov/study/NCT06409832) | RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment | — | University of Florence | RECRUITING |
[NCT06674772](https://clinicaltrials.gov/study/NCT06674772) | Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification | — | Hospital Universitari Vall d'Hebron Research Institute | RECRUITING |
[NCT06459635](https://clinicaltrials.gov/study/NCT06459635) | Migraine Attack Pain Phase Prediction Study | — | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | RECRUITING |
[NCT06617832](https://clinicaltrials.gov/study/NCT06617832) | Trial Designs for Evaluating Migraine Treatment | NA | University of Aarhus | RECRUITING |
226 publications have been identified in PubMed for migraine without aura. Research spans Epidemiology / Natural History (36%), Basic Science / Preclinical (28%), and Review / Meta-Analysis (14%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 82 | 36% |
Laboratory research | 64 | 28% |
Research summaries | 32 | 14% |
Clinical study results | 26 | 12% |
Testing and diagnosis research | 13 | 6% |
Patient case studies | 5 | 2% |
New treatment approaches | 4 | 2% |
Nitsche L (2026). [PMID: 41705319](https://pubmed.ncbi.nlm.nih.gov/41705319/). *Headache*. [Review / Meta-Analysis]
Ailani J (2026). [PMID: 41186275](https://pubmed.ncbi.nlm.nih.gov/41186275/). *Headache*. [Clinical Trial Publication]
Tourlas K (2026). [PMID: 41652664](https://pubmed.ncbi.nlm.nih.gov/41652664/). *Headache*. [Clinical Trial Publication]
Radmard A (2026). [PMID: 40392493](https://pubmed.ncbi.nlm.nih.gov/40392493/). *Drug Deliv Transl Res*. [Gene Therapy / Novel Therapeutics]
Jean J (2026). [PMID: 42175659](https://pubmed.ncbi.nlm.nih.gov/42175659/). *Headache*. [Clinical Trial Publication]
Chaudhry BA (2026). [PMID: 41574090](https://pubmed.ncbi.nlm.nih.gov/41574090/). *Brain Commun*. [Epidemiology / Natural History]
Mohamed MI (2026). [PMID: 41987034](https://pubmed.ncbi.nlm.nih.gov/41987034/). *J Headache Pain*. [Review / Meta-Analysis]
Zhang X (2026). [PMID: 41591775](https://pubmed.ncbi.nlm.nih.gov/41591775/). *JAMA Netw Open*. [Clinical Trial Publication]
Christensen RH (2026). [PMID: 41622925](https://pubmed.ncbi.nlm.nih.gov/41622925/). *Cephalalgia*. [Diagnostic / Biomarker]
Perrone U (2026). [PMID: 41630559](https://pubmed.ncbi.nlm.nih.gov/41630559/). *Expert Opin Drug Saf*. [Review / Meta-Analysis]