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mueller-weiss syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

mueller-weiss syndrome

MONDO:0035452

Also known as:Brailsford diseaseMueller-Weiss osteonecrosis of the tarsal bone

Overview

A rare bone disease characterized by spontaneous adult-onset tarsal navicular osteonecrosis. Patients present with chronic mid- and hindfoot pain, swelling and tenderness over the dorsomedial aspect of the midfoot, flattening of the medial longitudinal arch, and pes planovarus. Radiographic findings include comma-shaped deformity due to collapse of the lateral part of the navicular bone and medial or dorsal protrusion of a portion or the entire bone. The condition may be bilateral or asymmetric and associated with pathological fractures.

ResearchLimited published research (4 articles)

Diagnosis

Biomarker and diagnostic research for mueller-weiss syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for mueller-weiss syndrome.

4 publications have been identified in PubMed for mueller-weiss syndrome. Research spans Case Report / Case Series (75%) and Diagnostic / Biomarker (25%).

Recent Publications

Pabbisetti D (2026). [PMID: 41769514](https://pubmed.ncbi.nlm.nih.gov/41769514/). *Cureus*. [Case Report / Case Series]
Lin YC (2025). [PMID: 41515513](https://pubmed.ncbi.nlm.nih.gov/41515513/). *Diagnostics (Basel)*. [Diagnostic / Biomarker]
Adithya N (2025). [PMID: 39957946](https://pubmed.ncbi.nlm.nih.gov/39957946/). *J Orthop Case Rep*. [Case Report / Case Series]
Sitaula P (2024). [PMID: 39669017](https://pubmed.ncbi.nlm.nih.gov/39669017/). *J Orthop Case Rep*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:54 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:566943

GARD

Genetic and Rare Diseases Info Center

GARD:22283

Questions for Your Care Team

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mueller-weiss syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team