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A rare bone disease that arises due to secondary hyperparathyroidism in patients with chronic renal failure receiving dialysis characterized by 'uglifying' the appearance of the face
Features include very common findings: Abnormality of the dentition, Abnormal facial shape, Elevated circulating parathyroid hormone level, and Short stature; and common findings: Depression, Waddling gait, Abnormality of the lower limb, and High-frequency hearing impairment. 13 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 3 | Depression, Waddling gait, Anxiety |
Phenotype severity distribution: 4 very common features, 4 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for Sagliker syndrome.
4 publications have been identified in PubMed for Sagliker syndrome. Research spans Case Report / Case Series (100%).
Morantes Salazar MM (2026). [PMID: 41710863](https://pubmed.ncbi.nlm.nih.gov/41710863/). *Cureus*. [Case Report / Case Series]
Ren J (2026). [PMID: 42131771](https://pubmed.ncbi.nlm.nih.gov/42131771/). *Clin Nephrol Case Stud*. [Case Report / Case Series]
Ru Y (2024). [PMID: 38836368](https://pubmed.ncbi.nlm.nih.gov/38836368/). *Clinical nephrology*. [Case Report / Case Series]
García Romero JM (2024). [PMID: 39130819](https://pubmed.ncbi.nlm.nih.gov/39130819/). *Cureus*. [Case Report / Case Series]
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 12:51 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Sagliker syndrome
Arms and legs |
2 |
Abnormality of the lower limb, Abnormal finger morphology |
Head and neck | 1 | Abnormal facial shape |
Lab test results | 1 | Elevated circulating parathyroid hormone level |
Growth and development | 1 | Short stature |
Ears | 1 | High-frequency hearing impairment |
Bones and joints | 1 | Arthralgia |
AI-curated news mentioning Sagliker syndrome
Updated May 11, 2026
A case report details a patient with Sagliker syndrome who underwent parathyroidectomy, contributing to the understanding of this rare condition. The literature review provides insights into the clinical management of Sagliker syndrome.