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A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It includes two categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic syndrome with excess blasts-2.
Biomarker and diagnostic research for myelodysplastic syndrome with excess blasts has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
12 clinical trials registered, 5 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 6 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03383575](https://clinicaltrials.gov/study/NCT03383575) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome |
PHASE2 |
M.D. Anderson Cancer Center |
RECRUITING |
[NCT03128034](https://clinicaltrials.gov/study/NCT03128034) | 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia | PHASE1 | Fred Hutchinson Cancer Center | RECRUITING |
[NCT02727803](https://clinicaltrials.gov/study/NCT02727803) | Personalized NK Cell Therapy in CBT | PHASE2 | M.D. Anderson Cancer Center | RECRUITING |
[NCT06372717](https://clinicaltrials.gov/study/NCT06372717) | A Study to Investigate APL-4098 Alone and in Combination in Adults With AML or MDS | PHASE1 | Apollo Therapeutics Ltd | RECRUITING |
[NCT03670966](https://clinicaltrials.gov/study/NCT03670966) | 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome | PHASE1 | Fred Hutchinson Cancer Center | RECRUITING |
10 publications have been identified in PubMed for myelodysplastic syndrome with excess blasts. Research spans Case Report / Case Series (50%), Diagnostic / Biomarker (30%), and Epidemiology / Natural History (10%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 5 | 50% |
Testing and diagnosis research | 3 | 30% |
Disease patterns and progression | 1 | 10% |
New treatment approaches | 1 | 10% |
Albar RF (2026). [PMID: 41613507](https://pubmed.ncbi.nlm.nih.gov/41613507/). *Cureus*. [Case Report / Case Series]
Eifer M (2025). [PMID: 39978813](https://pubmed.ncbi.nlm.nih.gov/39978813/). *Journal of nuclear medicine : official publication, Society of Nuclear Medicine*. [Diagnostic / Biomarker]
Mori J (2025). [PMID: 40181449](https://pubmed.ncbi.nlm.nih.gov/40181449/). *Journal of medical case reports*. [Diagnostic / Biomarker]
Liu L (2025). [PMID: 40646469](https://pubmed.ncbi.nlm.nih.gov/40646469/). *BMC cancer*. [Diagnostic / Biomarker]
Drexler B (2025). [PMID: 40554414](https://pubmed.ncbi.nlm.nih.gov/40554414/). *Blood advances*. [Epidemiology / Natural History]
Moore ME (2024). [PMID: 38964162](https://pubmed.ncbi.nlm.nih.gov/38964162/). *Cancer genetics*. [Case Report / Case Series]
Gürbüz AF (2024). [PMID: 38995367](https://pubmed.ncbi.nlm.nih.gov/38995367/). *Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]*. [Case Report / Case Series]
Xie L (2024). [PMID: 38707905](https://pubmed.ncbi.nlm.nih.gov/38707905/). *Frontiers in immunology*. [Case Report / Case Series]
Mecham B (2024). [PMID: 38910768](https://pubmed.ncbi.nlm.nih.gov/38910768/). *Cureus*. [Case Report / Case Series]
Guo W (2024). [PMID: 38969929](https://pubmed.ncbi.nlm.nih.gov/38969929/). *Annals of hematology*. [Gene Therapy / Novel Therapeutics]