Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

myeloid neoplasm associated with PDGFRA rearrangement - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

myeloid neoplasm associated with PDGFRA rearrangement

MONDO:0015689

Also known as:myeloid and lymphoid neoplasms associated with PDGFRA rearrangementmyeloid and lymphoid neoplasms with PDGFRA rearrangementmyeloid/lymphoid neoplasms with PDGFRA rearrangement

Overview

A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRA gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic eosinophilic leukemia or, less commonly, as acute myeloid leukemia or T-lymphoblastic leukemia with eosinophilia. Patients usually present with eosinophilia, anemia, thrombocytopenia, neutrophilia, splenomegaly, lymphadenopathy, fever, sweating and/or weight loss. Tissue infiltration by eosinophils can manifest with skin rash, erythema, cough, neurological alterations, gastrointestinal symptoms or, rarely, endomyocardial fibrosis and restrictive cardiomyopathy.

Diagnosis

Biomarker and diagnostic research for myeloid neoplasm associated with PDGFRA rearrangement has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for myeloid neoplasm associated with PDGFRA rearrangement.

17 publications have been identified in PubMed for myeloid neoplasm associated with PDGFRA rearrangement. Research spans Case Report / Case Series (65%), Review / Meta-Analysis (18%), and Diagnostic / Biomarker (12%).

Research Type	Count	% of Total
Patient case studies	11	65%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:34 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:168947

GARD

Genetic and Rare Diseases Info Center

GARD:20106

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

myeloid neoplasm associated with PDGFRA rearrangement

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications