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Non-immune hydrops fetalis (NIHF), a form of HF, is a severe fetal condition defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities, and is the end-stage of a wide variety of disorders.
Features include: Low red blood cell count (anemia), Nonimmune hydrops fetalis, Congestive heart failure, and Hydrops fetalis.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Pregnancy and birth | 2 | Nonimmune hydrops fetalis, Hydrops fetalis |
Blood and immune system |
Biomarker and diagnostic research for non-immune hydrops fetalis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered. Interventions under study include other interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.
46 publications have been identified in PubMed for non-immune hydrops fetalis. Research spans Case Report / Case Series (52%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 24 | 52% |
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 1:00 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
1 |
Low red blood cell count (anemia) |
Heart and blood vessels | 1 | Congestive heart failure |
Age of onset: at birth.
Research summaries |
9 |
20% |
Disease patterns and progression | 7 | 15% |
Other research | 2 | 4% |
Testing and diagnosis research | 2 | 4% |
Clinical study results | 1 | 2% |
Laboratory research | 1 | 2% |
Ali K (2026). [PMID: 42158370](https://pubmed.ncbi.nlm.nih.gov/42158370/). *Front Pediatr*. [Epidemiology / Natural History]
Konstantinidou AE (2026). [PMID: 42165577](https://pubmed.ncbi.nlm.nih.gov/42165577/). *Pediatr Dev Pathol*. [Case Report / Case Series]
Sathian S (2026). [PMID: 41798503](https://pubmed.ncbi.nlm.nih.gov/41798503/). *Cureus*. [Case Report / Case Series]
Ochieng WO (2026). [PMID: 42221600](https://pubmed.ncbi.nlm.nih.gov/42221600/). *Pan Afr Med J*. [Case Report / Case Series]
Allen VM (2026). [PMID: 41775679](https://pubmed.ncbi.nlm.nih.gov/41775679/). *Prenat Diagn*. [Diagnostic / Biomarker]
Tamilarasan S (2026). [PMID: 41986063](https://pubmed.ncbi.nlm.nih.gov/41986063/). *BMJ Case Rep*. [Case Report / Case Series]
Eyupoglu M (2026). [PMID: 41806864](https://pubmed.ncbi.nlm.nih.gov/41806864/). *Z Geburtshilfe Neonatol*. [Case Report / Case Series]
Borthakur K (2026). [PMID: 41763666](https://pubmed.ncbi.nlm.nih.gov/41763666/). *BMJ Case Rep*. [Case Report / Case Series]
Almomani SA (2026). [PMID: 42181387](https://pubmed.ncbi.nlm.nih.gov/42181387/). *Cureus*. [Case Report / Case Series]
Al Hassan J (2026). [PMID: 42233396](https://pubmed.ncbi.nlm.nih.gov/42233396/). *Future Sci OA*. [Diagnostic / Biomarker]
AI-curated news mentioning non-immune hydrops fetalis
Updated Aug 24, 2026
A prospective cohort study highlights the incremental value of whole exome sequencing in improving diagnostic precision for non-immune hydrops fetalis. This research underscores the potential of advanced genetic testing in identifying underlying causes of this condition.