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A rare type of multiple myeloma in which the plasma cells synthesize but do not secrete immunoglobulins. As a result, none of the immunoglobulins appear out of the normal range. The symptoms are generally the same with those of immunoglobulin-secreting myeloma; however, the incidence of renal insufficiency is lower in non-secretory myeloma. The diagnosis can be missed because of the absence of monoclonal immunoglobulin in the serum or urine.
Biomarker and diagnostic research for non-secretory plasma cell myeloma has been reported in the published literature.
No clinical trials have been registered for non-secretory plasma cell myeloma.
24 publications have been identified in PubMed for non-secretory plasma cell myeloma. Research spans Case Report / Case Series (42%), Review / Meta-Analysis (25%), and Diagnostic / Biomarker (21%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 10 | 42% |
Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 4:50 AM UTC
Research summaries
6 |
25% |
Testing and diagnosis research | 5 | 21% |
Laboratory research | 2 | 8% |
Disease patterns and progression | 1 | 4% |
Xu K (2026). [PMID: 41568011](https://pubmed.ncbi.nlm.nih.gov/41568011/). *EJHaem*. [Case Report / Case Series]
Nakanishi Y (2026). [PMID: 41485914](https://pubmed.ncbi.nlm.nih.gov/41485914/). *Intern Med*. [Case Report / Case Series]
Lopes MMC (2026). [PMID: 41754860](https://pubmed.ncbi.nlm.nih.gov/41754860/). *Pharmaceuticals (Basel)*. [Review / Meta-Analysis]
Chen Y (2026). [PMID: 41338333](https://pubmed.ncbi.nlm.nih.gov/41338333/). *Clin Chim Acta*. [Diagnostic / Biomarker]
Vaxman I (2026). [PMID: 41944077](https://pubmed.ncbi.nlm.nih.gov/41944077/). *Hematol Oncol*. [Epidemiology / Natural History]
Ren Y (2026). [PMID: 41751254](https://pubmed.ncbi.nlm.nih.gov/41751254/). *Biomedicines*. [Basic Science / Preclinical]
McIlroy G (2026). [PMID: 41762084](https://pubmed.ncbi.nlm.nih.gov/41762084/). *Br J Hosp Med (Lond)*. [Review / Meta-Analysis]
Zhong J (2026). [PMID: 42100385](https://pubmed.ncbi.nlm.nih.gov/42100385/). *Front Oncol*. [Case Report / Case Series]
Hanbali A (2025). [PMID: 40700098](https://pubmed.ncbi.nlm.nih.gov/40700098/). *Hematol Rep*. [Review / Meta-Analysis]
Charliński G (2025). [PMID: 39206811](https://pubmed.ncbi.nlm.nih.gov/39206811/). *Adv Clin Exp Med*. [Diagnostic / Biomarker]