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A plasma cell myeloma lacking clinical manifestations and organ impairment.
Biomarker and diagnostic research for smoldering plasma cell myeloma has been reported in the published literature.
58 clinical trials registered, 26 recruiting. Interventions under study include other interventions, drug therapy, biologic therapy, and procedural interventions. Pipeline includes 6 PHASE3, 21 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05841550](https://clinicaltrials.gov/study/NCT05841550) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 3:00 PM UTC
The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple Myeloma |
PHASE1 |
Oslo University Hospital |
RECRUITING |
[NCT05136807](https://clinicaltrials.gov/study/NCT05136807) | Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies | — | M.D. Anderson Cancer Center | RECRUITING |
[NCT05283993](https://clinicaltrials.gov/study/NCT05283993) | A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH | — | Peking University First Hospital | RECRUITING |
[NCT06383143](https://clinicaltrials.gov/study/NCT06383143) | Promoting Diagnosis and Management of AL in Italy (ProDigALIty) | — | Fondazione IRCCS Policlinico San Matteo di Pavia | RECRUITING |
[NCT06237803](https://clinicaltrials.gov/study/NCT06237803) | European Myeloma Network (EMN) Sample Project | — | European Myeloma Network B.V. | RECRUITING |
123 publications have been identified in PubMed for smoldering plasma cell myeloma. Kisho has analyzed 82 by research type. Research spans Review / Meta-Analysis (46%), Basic Science / Preclinical (20%), and Clinical Trial Publication (11%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 38 | 46% |
Laboratory research | 16 | 20% |
Clinical study results | 9 | 11% |
Testing and diagnosis research | 7 | 9% |
Other research | 5 | 6% |
Disease patterns and progression | 5 | 6% |
Patient case studies | 1 | 1% |
New treatment approaches | 1 | 1% |
Mohty M (2026). [PMID: 41807348](https://pubmed.ncbi.nlm.nih.gov/41807348/). *Blood Cancer J*. [Review / Meta-Analysis]
Zanwar S (2026). [PMID: 41484090](https://pubmed.ncbi.nlm.nih.gov/41484090/). *Blood Cancer J*. [Diagnostic / Biomarker]
Sunil A (2026). [PMID: 41700260](https://pubmed.ncbi.nlm.nih.gov/41700260/). *Cureus*. [Review / Meta-Analysis]
Sra MS (2026). [PMID: 41133522](https://pubmed.ncbi.nlm.nih.gov/41133522/). *Leuk Lymphoma*. [Review / Meta-Analysis]
Zanwar S (2026). [PMID: 41571958](https://pubmed.ncbi.nlm.nih.gov/41571958/). *Nat Rev Clin Oncol*. [Review / Meta-Analysis]
Maura F (2026). [PMID: 41359792](https://pubmed.ncbi.nlm.nih.gov/41359792/). *Blood*. [Review / Meta-Analysis]
Maura F (2026). [PMID: 41061199](https://pubmed.ncbi.nlm.nih.gov/41061199/). *J Clin Oncol*. [Basic Science / Preclinical]
Hicks LK (2026). [PMID: 41494138](https://pubmed.ncbi.nlm.nih.gov/41494138/). *J Clin Oncol*. [Review / Meta-Analysis]
Chabrun F (2026). [PMID: 41876650](https://pubmed.ncbi.nlm.nih.gov/41876650/). *Nat Med*. [Epidemiology / Natural History]
Aquilina C (2026). [PMID: 42278213](https://pubmed.ncbi.nlm.nih.gov/42278213/). *Int J Mol Sci*. [Basic Science / Preclinical]
AI-curated news mentioning smoldering plasma cell myeloma
Updated Aug 25, 2026
A case study highlights hyperviscosity syndrome as a rare manifestation of immunoglobulin G kappa smoldering multiple myeloma, effectively treated with daratumumab. This finding contributes to the understanding of treatment options for this rare presentation.