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A rare ophthalmic disorder characterized by idiopathic orbital inflammation in which the specific target tissue is the optic nerve sheath. Patients typically present with ocular pain, pain on eye movement, visual symptoms with loss of vision progressing over several weeks, dyschromatopsia, and variable visual field defects. Orbital signs and symptoms may be present and include ptosis, ophthalmoplegia, and exophthalmos. Optic disk edema is observed in most cases. The condition is usually unilateral.
Biomarker and diagnostic research for optic perineuritis has been reported in the published literature.
No clinical trials have been registered for optic perineuritis.
44 publications have been identified in PubMed for optic perineuritis. Research spans Case Report / Case Series (66%), Epidemiology / Natural History (11%), and Diagnostic / Biomarker (9%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 29 | 66% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
5 |
11% |
Testing and diagnosis research | 4 | 9% |
Other research | 2 | 5% |
Laboratory research | 2 | 5% |
Research summaries | 1 | 2% |
Clinical study results | 1 | 2% |
Paris J (2026). [PMID: 42160723](https://pubmed.ncbi.nlm.nih.gov/42160723/). *Ocul Immunol Inflamm*. [Case Report / Case Series]
Cortes B (2026). [PMID: 41847281](https://pubmed.ncbi.nlm.nih.gov/41847281/). *Neuro-ophthalmology (Aeolus Press)*. [Case Report / Case Series]
Canestraro J (2026). [PMID: 41684879](https://pubmed.ncbi.nlm.nih.gov/41684879/). *Ocular oncology and pathology*. [Case Report / Case Series]
Lin HC (2026). [PMID: 41640497](https://pubmed.ncbi.nlm.nih.gov/41640497/). *Neuro-ophthalmology (Aeolus Press)*. [Case Report / Case Series]
Vampertzi O (2026). [PMID: 41635567](https://pubmed.ncbi.nlm.nih.gov/41635567/). *Cureus*. [Case Report / Case Series]
Espinoza S (2026). [PMID: 41771335](https://pubmed.ncbi.nlm.nih.gov/41771335/). *American journal of ophthalmology*. [Case Report / Case Series]
Besse B (2026). [PMID: 41657375](https://pubmed.ncbi.nlm.nih.gov/41657375/). *American journal of ophthalmology case reports*. [Case Report / Case Series]
Tuncer O (2026). [PMID: 41640500](https://pubmed.ncbi.nlm.nih.gov/41640500/). *Neuro-ophthalmology (Aeolus Press)*. [Diagnostic / Biomarker]
Handzic A (2026). [PMID: 41880720](https://pubmed.ncbi.nlm.nih.gov/41880720/). *J Fr Ophtalmol*. [Other]
Banaji SH (2026). [PMID: 41969835](https://pubmed.ncbi.nlm.nih.gov/41969835/). *Case Rep Ophthalmol*. [Case Report / Case Series]
AI-curated news mentioning optic perineuritis
Updated Feb 1, 2026
A rare case study highlights the concurrent presentation of idiopathic intracranial hypertension and bilateral optic perineuritis in a young boy. This unique clinical entity contributes to the understanding of these conditions and their potential overlap.