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Oral Cavity Squamous Cell Carcinoma — NIH Grants & Funding

MONDO:0004958

Funding Landscape

Oral Cavity Squamous Cell Carcinoma has a robust NIH research funding landscape with 77 funded grants and $83.9M in total funding over the period.

77funded grants from NIH

Portfolio: $34.8MCumulative: $83.9M55 active22 completed96 PIs49 institutions

+20% YoY(FY2024 vs FY2025)

12 new grants started in the last 12 months.

By Research Theme

Basic Science

Translational

Biomarker / Dx

Epi / Nat. History

Clinical

Medical Device

Gene/Cell Therapy

1 additional grant classified as “Other” (multi-disciplinary, infrastructure, etc.).

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$16.3M

FY22

$19.5M

FY23

$20.7M

FY24

$24.8M

FY25

$2.7M

FY26

By Funding Mechanism

R01

F31

R21

R03

R56

U01

Funding Gap Analysis

Cross-referencing NIH grants against published research and clinical trials to identify funding-evidence gaps for Oral Cavity Squamous Cell Carcinoma. Strongest funded area: Basic Science. Largest gap: Basic Science.

Epidemiology / Natural HistoryFunded, Few Publications

6 funded grants in Epidemiology / Natural History but only 0 related publications found for oral cavity squamous cell carcinoma. This may indicate early-stage research that hasn't yet produced published results.

Basic ScienceFunded, Few Publications

34 funded grants in Basic Science but only 0 related publications found for oral cavity squamous cell carcinoma. This may indicate early-stage research that hasn't yet produced published results.

Biomarker / DiagnosticsFunded, Few Publications

13 funded grants in Biomarker / Diagnostics but only 0 related publications found for oral cavity squamous cell carcinoma. This may indicate early-stage research that hasn't yet produced published results.

Translational / Drug DevelopmentFunded, Few Publications

16 funded grants in Translational / Drug Development but only 0 related publications found for oral cavity squamous cell carcinoma. This may indicate early-stage research that hasn't yet produced published results.

Clinical ResearchFunded, Few Publications

4 funded grants in Clinical Research but only 0 related publications found for oral cavity squamous cell carcinoma. This may indicate early-stage research that hasn't yet produced published results.

Note: Publication data is not yet available for this disease. Gap analysis is based on grant and trial data only.

Basic Science(34)

Basic ScienceZIACompleted

Enhancing anti-tumor immunity in head and neck neoplasms

Allen, Clint·DIVISION OF BASIC SCIENCES - NCI

$4,850,901 (FY2025)

Oral Cavity Squamous Cell Carcinoma — NIH Grants & Funding

Funding Landscape

By Research Theme

Funding by Fiscal Year

By Funding Mechanism

Funding Gap Analysis

Basic Science(34)

Enhancing anti-tumor immunity in head and neck neoplasms

Elucidating subclonal evolution and fitness dynamics in oral carcinogenesis

Functions of IKK alpha in Skin Homeostasis and Skin Tumorigenesis

An organ on-a-chip model of oral cancer and bone invasion

Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments

Defining the β-catenin/CBP-catenin/CBP axis in head and neck cancer

Investigating a new vulnerability in oral squamous cell carcinoma

Bitter taste receptors in oral cancer tumor-associated macrophages

Oral and Craniofacial Bone Regeneration using MicroRNA Modulation

3D Culture Models of Partial-EMT and Its Regulation in Oral Cavity Squamous Cell Carcinoma

Translational(16)

Reprogramming the Tumor-Immune Interface in Oral Cancer

Immune determinants of progression from Oral Epithelial Dysplasia to Oral Squamous Cell Carcinoma by precision multiplexed imaging

Inhibition of Hedgehog Signaling as a Therapeutic Strategy for OSCC

Cadherins, contact normalization, and targeting podoplanin to treat oral cancer

Formulation, Evaluation, and Phase 0 Trial of Nanoparticle Releasing Oral Thin Film for OSCC Chemoprevention

CD 1530, an RAR Gamma Agonist for Oral Cavity Squamous Cell Carcinoma Prevention

Inhibiting mitochondrial complex I to improve cetuximab efficacy in oral cancer

Targeting TRPC1: A Novel Approach to Treat Oral Cancer

Assessment of Chemopreventive Effects of a Mucoadhesive Fenretinide Patch on Premalignant Oral Epithelial Lesions

Targeting the stress-specific function of replication protein A in oral squamous cell carcinoma

Clinical(4)

Clinical Studies for Improving Survival Rates for Oral Cancer Patients in Low Resource Settings

Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition

The REASON Score: An Epigenetic And Clinicopathologic Score to Predict Risk of Poor Survival in Early Stage Oral Squamous Cell Carcinoma Patients

Dissecting the heterogeneity of oral cancer pain

Epi / Nat. History(6)

Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI Approaches

Oral Dysplasias to Carcinomas: Multi-omics Study of Progression

Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patients

Genetic Alterations That Confer High Risk to Oral Premalignant Lesions

Chemoprevention of Electronic Cigarette Promoted Oral Squamous Cell Carcinoma

Defining age-associated alterations in oral squamous cell carcinoma

Gene/Cell Therapy(1)

Defining the mutational pathogenesis of oral preneoplasia

Biomarker / Dx(13)

Precision DNA methylation test to reduce oral cancer disparities in African Americans patients residing in low-resource settings

Immune and transcriptomic biomarkers of progressive oral premalignant lesions

Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool

Validating the hybrid epithelial/mesenchymal state as a biomarker of treatment response and outcomes in head and neck cancer

Deep Learning Image Analysis Algorithms to Improve Oral Cancer Risk Assessment for Oral Potentially Malignant Disorders

Oral Cavity Quantitative Histomorphometric Risk Classifier (OHbIC) in Oral Cavity Squamous Cell Carcinoma (OC-SCC)

Decoding FTIR-based multimodal imaging for risk assessment of precancerous oral lesions

Optimizing Oral Cancer Screening and Precision Management of Potentially Malignant Oral Lesions

Somatic Mutations in Tissue and Saliva as Prognostic and Screening Biomarkers for Oral Premalignancy

Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy

Medical Device(2)

1,3-Thioureas as First In Class Mitochondrial Inhibitors to Treat Oral Cancer

Targeting OSCC cells with a lozenge to treat oral cancer

Other(1)

Modeling Oral Cancer in Primary Organoid Culture

Adjacent Research(15 grants)

Other(15)

Unraveling the Molecular Underpinnings of Premalignant Oral Lesion Transformation into Head and Neck Cancer

The biological mechanisms of racial disparity in head and neck cancer

PROSPECT: Premalignant Oral Lesions Pathology and Epigenetic Risk Prediction Tool

Harnessing the nervous system to overcome resistance to immunotherapy in oral cancer

Contribution of Truncated TrkB Isoform in Oral Cancer Pain

Health-associated oral bacteria as anti-cancer and immunomodulatory agents in oral cancer

Leveraging single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral cancer

The role of Fusobacterium nucleatum and Candida albicans interkingdom interactions in promoting OSCC

Elucidating mechanisms of cellular communication critical for head and neck cancer progression and metastasis.

Data-driven Diagnostics using Multimodal- AI Assisted Approaches for Early Cancer Detection

Top Funded Institutions

Top Principal Investigators