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peripheral motor neuropathy-dysautonomia syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

peripheral motor neuropathy-dysautonomia syndrome

MONDO:0009648

Also known as:Lisker-Garcia-Ramos syndromemotor neuropathy, peripheral, with dysautonomia

Overview

Peripheral motor neuropathy-dysautonomia syndrome is characterized by distal, slowly progressive muscular weakness, childhood-onset amyotrophy, autonomic dysfunction characterized by profuse sweating, distal cyanosis related to cold weather, orthostatic hypotension, and esophageal achalasia. It has been described in two sisters. Inheritance appears to be autosomal recessive.

ResearchLimited published research (1 article)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for peripheral motor neuropathy-dysautonomia syndrome.

1 publication has been identified in PubMed for peripheral motor neuropathy-dysautonomia syndrome. Research spans Review / Meta-Analysis (100%).

Recent Publications

Bevilacqua JA (2026). [PMID: 42024697](https://pubmed.ncbi.nlm.nih.gov/42024697/). *Rev Med Chil*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 10:41 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:252320

Orphanet

European rare disease database

Orphanet:2400

GARD

Genetic and Rare Diseases Info Center

GARD:3791

Questions for Your Care Team

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peripheral motor neuropathy-dysautonomia syndrome

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team