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Pilocytic astrocytoma is a rare subtype of low-grade glioma of the central nervous system characterized by a well circumscribed, often cystic, brain tumor with a discrete mural nodule and long, hair-like projections that extend from the neoplastic astrocytes. Depending on the primary localization and the size of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), blurred vision, decreased visual acuity, ataxia and/or nystagmus, among others. It is most commonly located in the cerebellum, but occurrence in the hypothalamus, brain stem, optic chiasma, and hemispheres has also been reported.
Biomarker and diagnostic research for pilocytic astrocytoma has been reported in the published literature.
5 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and procedural interventions. Pipeline includes 1 PHASE4, 2 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06915649](https://clinicaltrials.gov/study/NCT06915649) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
— |
University Hospital, Montpellier |
UNKNOWN |
[NCT01089101](https://clinicaltrials.gov/study/NCT01089101) | Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma | PHASE1 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT04541082](https://clinicaltrials.gov/study/NCT04541082) | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | PHASE1 | Jazz Pharmaceuticals | RECRUITING |
[NCT04065776](https://clinicaltrials.gov/study/NCT04065776) | Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma | NA | St. Jude Children's Research Hospital | UNKNOWN |
[NCT03975829](https://clinicaltrials.gov/study/NCT03975829) | Pediatric Long-Term Follow-up and Rollover Study | PHASE4 | Novartis Pharmaceuticals | ACTIVE_NOT_RECRUITING |
235 publications have been identified in PubMed for pilocytic astrocytoma. Research spans Case Report / Case Series (41%), Basic Science / Preclinical (16%), and Review / Meta-Analysis (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 90 | 41% |
Laboratory research | 35 | 16% |
Research summaries | 30 | 14% |
Testing and diagnosis research | 25 | 11% |
Disease patterns and progression | 18 | 8% |
Other research | 9 | 4% |
New treatment approaches | 6 | 3% |
Clinical study results | 5 | 2% |
Yu T (2026). [PMID: 41691591](https://pubmed.ncbi.nlm.nih.gov/41691591/). *Virchows Archiv : an international journal of pathology*. [Epidemiology / Natural History]
Panzo N (2026). [PMID: 41640498](https://pubmed.ncbi.nlm.nih.gov/41640498/). *Neuro-ophthalmology (Aeolus Press)*. [Case Report / Case Series]
Ong SRK (2026). [PMID: 41690762](https://pubmed.ncbi.nlm.nih.gov/41690762/). *Radiologia*. [Gene Therapy / Novel Therapeutics]
Bassi Y (2026). [PMID: 41952735](https://pubmed.ncbi.nlm.nih.gov/41952735/). *Surg Neurol Int*. [Case Report / Case Series]
Lian F (2026). [PMID: 41879092](https://pubmed.ncbi.nlm.nih.gov/41879092/). *J Pathol*. [Basic Science / Preclinical]
Gaggero G (2026). [PMID: 41738874](https://pubmed.ncbi.nlm.nih.gov/41738874/). *J Pediatr Hematol Oncol*. [Diagnostic / Biomarker]
Masroor M (2026). [PMID: 41660354](https://pubmed.ncbi.nlm.nih.gov/41660354/). *Surg Neurol Int*. [Case Report / Case Series]
Senyurek S (2026). [PMID: 41863652](https://pubmed.ncbi.nlm.nih.gov/41863652/). *Neurosurg Rev*. [Clinical Trial Publication]
Paker B (2026). [PMID: 41956359](https://pubmed.ncbi.nlm.nih.gov/41956359/). *J Neurol Surg A Cent Eur Neurosurg*. [Basic Science / Preclinical]
Gerasimou P (2026). [PMID: 41659712](https://pubmed.ncbi.nlm.nih.gov/41659712/). *Front Oncol*. [Case Report / Case Series]
AI-curated news mentioning pilocytic astrocytoma
Updated Mar 16, 2026
Recent research explores MEK inhibition in adult patients with pilocytic astrocytomas, highlighting potential therapeutic avenues. The study contributes to understanding treatment options for this rare brain tumor.
A new study identifies high-grade astrocytoma with piloid features as a distinct and aggressive clinicogenomic entity, separate from pilocytic astrocytoma. This discovery could impact future research and treatment strategies for these tumors.