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pleomorphic xanthoastrocytoma (PXA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pleomorphic xanthoastrocytoma

MONDO:0016690

Also known as:PXApleomorphic Xantho-astrocytoma

Find Clinical TrialsTrials

Overview

A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults.

Clinical Trials6 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for pleomorphic xanthoastrocytoma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and procedural interventions. Pipeline includes 1 PHASE4, 2 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04541082](https://clinicaltrials.gov/study/NCT04541082)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:251607

GARD

Genetic and Rare Diseases Info Center

GARD:10631

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Patient case studies	34	46%
Laboratory research	14	19%
Clinical study results	9	12%
Research summaries	7	9%
Testing and diagnosis research	5	7%
Disease patterns and progression	4	5%
New treatment approaches	1	1%

pleomorphic xanthoastrocytoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications