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plastic bronchitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

plastic bronchitis

MONDO:0018597

Also known as:croupous bronchitisfibrinous bronchitispseudo-membranous bronchitis

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Overview

A lymphatic flow disorder that causes severe respiratory issues. In children with plastic bronchitis, lymph fluid builds in the airways and forms rubbery or caulk-like plugs (known as casts). These casts block the airways, making it difficult to breathe.

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials1 registered

Diagnosis

Biomarker and diagnostic research for plastic bronchitis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for plastic bronchitis. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for plastic bronchitis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for plastic bronchitis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include procedural interventions. Research is primarily sponsored by academic and government institutions.

159 publications have been identified in PubMed for plastic bronchitis. Research spans Case Report / Case Series (29%), Epidemiology / Natural History (26%), and Diagnostic / Biomarker (11%).

Research Type	Count	% of Total
Patient case studies	46	29%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:29 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:439881

GARD

Genetic and Rare Diseases Info Center

GARD:21835

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→What is the current development status of alteplase, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

plastic bronchitis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Unilateral "white lung" in a child revealing plastic bronchitis: A reversible cause of airway obstruction.

Chylopericardium and Plastic Bronchitis From Thoracic Duct Dysfunction: A Multimodality Approach.

plastic bronchitis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Unilateral "white lung" in a child revealing plastic bronchitis: A reversible cause of airway obstruction.

Chylopericardium and Plastic Bronchitis From Thoracic Duct Dysfunction: A Multimodality Approach.