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polydactyly of an index finger (PPD3) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

polydactyly of an index finger

MONDO:0008271

Also known as:PPD3polydactyly, preaxial type 3preaxial polydactyly type 3

Overview

Polydactyly of an index finger or PPD3 is a form of preaxial polydactyly of fingers, a limb malformation syndrome, where the thumb is replaced by one or two triphalangeal digits with dermatoglyphic pattern specific of the index finger. Two forms of PPD3 have been characterized: unilateral and bilateral. There have been no further descriptions in the literature since 1962.

GeneticsAutosomal dominant

ResearchLimited published research (4 articles)

Clinical Presentation

Features include: Triphalangeal thumb and Preaxial polydactyly.

Explore clinical features

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for polydactyly of an index finger.

4 publications have been identified in PubMed for polydactyly of an index finger. Research spans Other (25%), Case Report / Case Series (25%), and Basic Science / Preclinical (25%).

Recent Publications

Aouchiche K (2025). [PMID: 39938560](https://pubmed.ncbi.nlm.nih.gov/39938560/). *European journal of endocrinology*. [Epidemiology / Natural History]
Zhu Y (2025). [PMID: 40056834](https://pubmed.ncbi.nlm.nih.gov/40056834/). *Journal of plastic, reconstructive & aesthetic surgery : JPRAS*. [Case Report / Case Series]
Nguyen TN (2024). [PMID: 38864382](https://pubmed.ncbi.nlm.nih.gov/38864382/). *Molecular genetics & genomic medicine*. [Basic Science / Preclinical]
Baldwin AJ (2024). [PMID: 37131334](https://pubmed.ncbi.nlm.nih.gov/37131334/). *Hand (N Y)*. [Other]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:174600

Orphanet

European rare disease database

Orphanet:93337

GARD

Genetic and Rare Diseases Info Center

GARD:2256

Questions for Your Care Team

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polydactyly of an index finger

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

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